Novel DNA-binding proteins and uses thereof
First Claim
Patent Images
1. An isolated, non-naturally occurring DNA-binding polypeptide comprising:
- at least one TALE-repeat unit;
an N-cap polypeptide; and
a C-cap polypeptide, wherein the C-cap polypeptide comprises a fragment of a TALE protein.
2 Assignments
0 Petitions
Accused Products
Abstract
Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
-
Citations
26 Claims
-
1. An isolated, non-naturally occurring DNA-binding polypeptide comprising:
-
at least one TALE-repeat unit; an N-cap polypeptide; and a C-cap polypeptide, wherein the C-cap polypeptide comprises a fragment of a TALE protein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
-
Specification