Composition for Treating Dry Eye and Related Methods of Manufacture and Methods of Use

• US 20110301250A1
• Filed: 08/22/2011
• Published: 12/08/2011
• Est. Priority Date: 03/31/2005
• Status: Abandoned Application

• Current Assignee: Erning Xia, Joseph Salamone, Liu X. Michael
• Original Assignee: Erning Xia, Joseph Salamone, Liu X. Michael
• Inventors: Xia, Erning, Liu, X. Michael, Salamone, Joseph
• Application Number:
  US13/214,306
• Publication Number:
  US 20110301250A1
• Time in Patent Office: Days
• US Class Current: 514/779
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 31/717 Celluloses
• CPC Class Codes: A61K 31/737 Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate A61K31/727 takes precedence
• CPC Class Codes: A61K 31/765 Polymers containing oxygen
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61P 27/02 Ophthalmic agents

Abstract

The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.

Claims

1. A dry eye composition comprising an aqueous solution that comprises carboxy-containing polymer at a concentration from about 0.01 to about 2 percent by weight of the solution, and a single polyol at a concentration from about 0.01 to about 2 percent by weight of the solution, wherein the carboxy-containing polymer comprises a carbomer, and wherein the polyol contains 2 to 6 carbon atoms.

2. The dry eye composition of claim 1, wherein the polyol contains 2 to 4 carbon atoms.

3. The dry eye composition of claim 1, wherein the polyol is glycerin.

4. The dry eye composition of claim 1, wherein the carboxy-containing polymer has a molecular weight in a range from 90 kDa to 700 kDa.

5. The dry eye composition of claim 1, wherein the concentration of the carboxy-containing polymer is from about 0.01 to about 1.2 percent by weight of the solution, and the concentration of the polyols is from about 0.01 to about 1 percent by weight of the solution.

6. The dry eye composition of claim 5, wherein the composition has an osmolality from about 240 mOsm/kg to about 320 mOsm/kg.

7. The dry eye composition of claim 1, wherein the polyol is selected from the group consisting of glycerin, ethylene glycol, propylene glycol, sorbitol, mannitol and monosaccharides.