Microcapsule for local treatment of a tumor and method for positioning a magnetic gradient field guiding magnetic nanoparticles to a target location as well as apparatus for positioning a magnetic gradient field

• US 20110301452A1
• Filed: 06/02/2011
• Published: 12/08/2011
• Est. Priority Date: 06/07/2010
• Status: Abandoned Application

• Current Assignee: Siemens AG
• Original Assignee: Siemens AG
• Inventors: Maschke, Michael, Klingenbeck, Klaus
• Application Number:
  US13/151,330
• Publication Number:
  US 20110301452A1
• Time in Patent Office: Days
• US Class Current: 600/424
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable or resorptive
• CPC Class Codes: A61B 2034/2051 Electromagnetic tracking systems
• CPC Class Codes: A61B 2090/376 using X-rays, e.g. fluoroscopy
• CPC Class Codes: A61B 2090/3762 using computed tomography systems [CT]
• CPC Class Codes: A61B 2090/392 Radioactive markers
• CPC Class Codes: A61B 2090/3954 magnetic, e.g. NMR or MRI
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 2090/3995 Multi-modality markers
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 34/70 Manipulators specially adapted for use in surgery
• CPC Class Codes: A61B 34/73 Manipulators for magnetic surgery
• CPC Class Codes: A61K 31/136 having the amino group directly attached to the aromatic ring, e.g. benzeneamine
• CPC Class Codes: A61K 31/704 attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin digitoxin A61K31/7048
• CPC Class Codes: A61K 49/0419 Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
• CPC Class Codes: A61K 51/1251 micro- or nanospheres, micro- or nanobeads, micro- or nanocapsules
• CPC Class Codes: A61K 9/5094 Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
• CPC Class Codes: A61M 2025/0166 Sensors, electrodes or the like for guiding the catheter to a target zone, e.g. image guided or magnetically guided
• CPC Class Codes: A61M 25/0105 Steering means as part of the catheter or advancing means; Markers for positioning systems for detection of markers A61B
• CPC Class Codes: A61M 25/0127 Magnetic means; Magnetic markers
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027
• CPC Class Codes: A61N 5/1007 : Arrangements or means for the introduction of sources into the body
• CPC Class Codes: A61P 35/00 : Antineoplastic agents

Abstract

A microcapsule for the local treatment of a tumor is proposed. The microcapsule has a support material forming a casing for the microcapsule, an active agent that damages tumor cells, a marker material suitable for use as an x-ray marker, and at least one magnetic nanoparticle. The active agent in particular destroys the tumor cells.

Claims

1-13. -13. (canceled)

14. A microcapsule for a local treatment of a tumor, comprising:

a casing comprising a support material;

an active agent that damages tumor cells;

a marker comprising a marker material that is suitable for use as an x-ray marker; and

a magnetic nanoparticle.

15. The microcapsule as claimed in claim 14, wherein the active agent is a radioactive agent that is selected from the group consisting of:

lutetium-177, iron-59, gallium-67.

16. The microcapsule as claimed in claim 14, wherein the active agent is an active chemotherapy agent that comprises a doxorubicin and/or a mitoxantrone.

17. The microcapsule as claimed in claim 14, wherein the support material is a biodegradable support material that is selected from the group consisting of:

a polymer, a polyethylene glycol, a polyacrylate, and a polyethylene oxide.

18. The microcapsule as claimed in claim 14, wherein the marker material is biodegradable that comprises an iodine and/or a barium sulfate.

19. The microcapsule as claimed in claim 14, wherein the magnetic nanoparticle is based on iron (III) oxide and/or iron (II,III) oxide with a diameter between 10 to 300 nm.

20. The microcapsule as claimed in claim 19, wherein the diameter of the magnetic nanoparticle is between 50 to 100 nm.

21. The microcapsule as claimed in claim 20, wherein the diameter of the magnetic nanoparticle is 80 nm.

22. A method for positioning a magnetic gradient field guiding a magnetic nanoparticle of a microcapsule to a target location, comprising:

guiding a catheter comprising an electromagnetic position sensor to the target location; and

displaying a focal point to the target location based on a signal from the position sensor.

23. The method as claimed in claim 22, wherein the focal point is characterized by a maximum gradient and is displaced to the target location after the catheter is guided to the target location so that a signal measured at the position sensor is at a maximum.

24. The method as claimed in claim 22, wherein the focal point is displaced at least partially by correspondingly actuating an electromagnet and/or at least partially by mechanically displaying a magnet producing the gradient field.

25. The method as claimed in claim 22, wherein the focal point is displaced at least partially by displaying an apparatus supporting a target object encompassing the target location.

26. The method as claimed in claim 22, wherein the focal point is displaced automatically based on a magnetic field map describing the gradient field and/or by an optimization method.

27. The method as claimed in claim 22, wherein the catheter injects the microcapsules containing the magnetic nanoparticle.

28. An apparatus for positioning a magnetic gradient field guiding a magnetic nanoparticle of a microcapsule to a target location, comprising:

a magnet that produces the magnetic gradient field;

a catheter comprising a position sensor; and

a control device that is configured to;

guide the catheter to the target location; and

display a focal point to the target location based on a signal from the position sensor.

29. The apparatus as claimed in claim 28, further comprising a mechanical device actuated by the control device for mechanically displaying the magnet.

30. The apparatus as claimed in claim 28, further comprising an apparatus supporting a target object encompassing the target location and a mechanical device actuated by the control device for mechanically displaying the apparatus.

31. The apparatus as claimed in claim 28, wherein the magnet comprises an actuatable electromagnet.

32. The apparatus as claimed in claim 28, wherein the position sensor comprises a coil.