Antimicrobial lubricant

• US 20110301553A1
• Filed: 06/04/2010
• Published: 12/08/2011
• Est. Priority Date: 06/04/2010
• Status: Abandoned Application

• Current Assignee: Smiths Medical ASD, Inc. (Smiths Group International Holdings Ltd.)
• Original Assignee: Smiths Medical ASD, Inc. (Smiths Group International Holdings Ltd.)
• Inventors: Goral, David, Chheda, Harsh, Wronka, Jane
• Application Number:
  US12/801,348
• Publication Number:
  US 20110301553A1
• Time in Patent Office: Days
• US Class Current: 604/265
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/452 Lubricants
• CPC Class Codes: A61L 2400/10 Materials for lubricating medical devices
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61M 2025/0056 provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
• CPC Class Codes: A61M 25/0606 "Over-the-needle" catheter assemblies, e.g. I.V. catheters
• CPC Class Codes: B05D 2601/28 Metals
• CPC Class Codes: B05D 5/08 to obtain an anti-friction or anti-adhesive surface rendering particulate materials free-flowing in general, e.g. making them hydrophobic B01J2/30
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

An antimicrobial lubricant combines an antimicrobial agent, preferably silver based, with a silicone lubricant. This is achieved by first formulating a lubricant solution that has a non-volatile silicone lubricant and a volatile solvent carrier. An antimicrobial agent is added to the lubricant solution. The solution is then subjected to ultrasonic energy so that the antimicrobial agent is uniformly mixed with the lubricant in the solution. The solution containing the antimicrobial lubricant may be sprayed onto a medical device, for example the outer surface of the catheter of a peripheral IV catheter. After the solvent flashes off, a coat of uniform antimicrobial lubricant is formed on the catheter surface. The antimicrobial lubricant coating facilitates the insertion of the catheter to a patient, and at the same time prevents the growth of microorganisms from the device and infection to the patient.

Claims

1. Medical device comprising a lubricious silver based antimicrobial coating that acts as a lubricant to facilitate the contact interaction of the device with a patient and a deterrent to prevent or substantially eliminate the growth of microorganisms on the device and at least those portions of the patient that the device comes into contact with to thereby prevent infection to the patient.

2. Medical device of claim 1, wherein the lubricious antimicrobial coating is formed on the medical device by spraying the medical device with a solution having a silver based antimicrobial agent mixed with a silicone lubricant.

3. Medical device of claim 2, wherein the solution comprises a silver antimicrobial agent with either zeolite carrier (Ag-Z) or glass carrier (Ag-G) mixed with the silicone lubricant, the solution having a volatile component and a non-volatile component.

4. Medical device of claim 1, wherein the lubricious antimicrobial coating is formed on the medical device by dipping the medical device into a silicone lubricant solution having a silver based antimicrobial agent mixed therein.

5. Medical device of claim 1, wherein the medical device includes any of the following:

infusion sites and ports, inserters for the infusion sites and ports, cannula and needle devices, catheters including at least epidural and peripheral IV catheters.

6. Medical device of claim 1, wherein the medical device comprises a base, a catheter extending from the base and a needle extending through and movable relative to the catheter, and wherein at least the outer diameter surface of the catheter is coated by the lubricious antimicrobial coating.

7. Medical device of claim 6, wherein the outer surface of the base is also coated with the lubricious antimicrobial coating.

8. Medical device of claim 1, wherein the coating comprises a lubricant and an antimicrobial agent, and wherein the lubricant is a silicone based lubricant comprising polydialkylsiloxanes and preferably polydimethyl siloxane.

9. An antimicrobial lubricant comprising:

a silver based antimicrobial agent combined with a silicone based lubricant, the antimicrobial lubricant adapted to coat a medical device for use with a patient, the antimicrobial lubricant acts as a lubricant to facilitate the contact interaction of the device with the patient, the antimicrobial lubricant further acting as a deterrent to prevent or substantially eliminate the growth of microorganisms on the device and at least those portions of the patient that the device comes into contact with to thereby prevent infection to the patient.

10. The antimicrobial lubricant of claim 9, wherein the silicone based lubricant comprises polydialkylsiloxanes and preferably polydimethyl siloxane.

11. The antimicrobial lubricant of claim 9, wherein the silver based antimicrobial agent comprises either Ag-Z (silver with zeolite carrier) or Ag-G (silver with glass carrier).

12. The antimicrobial lubricant of claim 9, wherein the antimicrobial agent is mixed with a silicone lubricant in a solution, the silver based antimicrobial agent having either zeolite carrier (Ag-Z) or glass carrier (Ag-G), the silicone lubricant having a volatile component and a non-volatile component, the volatile component flashing off after the medical device is coated with the antimicrobial lubricant so that the medical device is coated by the antimicrobial lubricant.

13. The antimicrobial lubricant of claim 9, wherein the antimicrobial lubricant is formed on the medical device by spraying the medical device with a solution having mixed therein the silver based antimicrobial agent and the silicone based lubricant.

14. The antimicrobial lubricant of claim 9, wherein the antimicrobial lubricant is formed on the medical device by dipping the device into a solution having mixed therein the silver based antimicrobial agent and the silicone based lubricant.

15. The antimicrobial lubricant of claim 9, wherein the medical device includes any of the following:

infusion sites and ports, inserters for the infusion sites and ports, cannula and needle devices, and catheters including at least epidural and IV catheters.

16. The antimicrobial lubricant of claim 9, wherein the medical device comprises a catheter, a base wherefrom the catheter extends and a needle extending through and movable relative to the catheter, and wherein at least the outer diameter surface of the catheter is coated by the antimicrobial lubricant.

17. The antimicrobial lubricant of claim 16, wherein the outer surface of the base is also coated with the antimicrobial lubricant.

18. A catheter device comprising a needle having an outer diameter extending through and movable relative to a catheter having an inner diameter, the outer diameter surface of the needle in contact with the inner diameter surface of the catheter, the catheter having coated along its length at its outer diameter surface a lubricious antimicrobial coating that facilitates the insertion of the catheter and the needle to a patient and acts as a deterrent to prevent or substantially eliminate the growth of microorganisms at the device and at least those portions of the patient that the device comes into contact with to thereby prevent infection to the patient.

19. Catheter device of claim 18, wherein the lubricious antimicrobial coating comprises a silicone based lubricant and a silver based antimicrobial agent.

20. Catheter device of claim 19, wherein the silicone based lubricant comprises polydialkylsiloxanes and preferably polydimethyl siloxane.

21. Catheter device of claim 18, wherein the antimicrobial coating is formed on the outer diameter surface of the catheter by spraying thereon a solution having the silver based antimicrobial agent mixed with the silicone based lubricant, the silver based antimicrobial agent having either zeolite carrier (Ag-Z) or glass carrier (Ag-G), the silicone lubricant having a volatile component and a non-volatile component, the volatile component flashing off after the medical device is coated with the antimicrobial lubricant so that the medical device is coated by the antimicrobial lubricant.

22. Catheter device of claim 18, further comprising a base wherefrom the catheter extends, wherein the outer surface of the base is also coated with the lubricious antimicrobial coating.

23. An antimicrobial lubricant comprising an antimicrobial agent mixed with a silicone based lubricant in a solution, wherein the antimicrobial agent is Triclosan and the lubricant includes polydialkylsiloxanes preferably polydimethyl siloxane, the solution including a volatile solvent, wherein the Triclosan is mixed with the polydimethyl siloxane in the solution, the solution applied to the surface of a medical by spraying, whereby after the volatile solvent evaporates, the surface of the medical device is coated by a layer of the antimicrobial lubricant.

24. A method of making an antimicrobial lubricant comprising the steps of:

a) combining a solvent and a silicone base lubricant to formulate a lubricant solution;

b) adding a silver based antimicrobial agent in the lubricant solution;

c) subjecting the antimicrobial agent added lubricant solution to ultrasonic energy to mix the antimicrobial agent with the silicone based lubricant to form an antimicrobial lubricant solution; and

d) evaporating the solvent from the antimicrobial lubricant solution to obtain the antimicrobial lubricant.

25. The method of claim 24, wherein the silicone based lubricant comprises polydialkylsiloxanes and preferably polydimethyl siloxane.

26. The method of claim 24, wherein the antimicrobial agent comprises either silver with zeolite carrier (Ag-Z) or silver with glass carrier (Ag-G).

27. The method of claim 24, comprising the step of spraying the antimicrobial lubricant solution on a medical device before step (d) so that the antimicrobial lubricant is formed as a lubricious antimicrobial coating on the medical device.