Analyte Sensors and Methods

• US 20110303539A1
• Filed: 05/11/2011
• Published: 12/15/2011
• Est. Priority Date: 10/31/2006
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Chen, Ting, Feldman, Benjamin J.
• Granted Patent: US 8,972,198 B2
• Time in Patent Office: Days
• US Class Current: 204/406
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 27/26 by investigating electrochemical variables; by using electrolysis or electrophoresis
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875

Abstract

Methods of determining analyte concentration. The methods use a fraction of the predicted total charge, from analyte electrolysis, instead of using time, for determination of a data collection endpoint. The total charge is then extrapolated from the data collection endpoint. The analyte concentration is determined from the total charge.

Claims

1-8. -8. (canceled)

9. An analyte sensor system comprising:

a meter that applies a current to a working and a counter electrode of an electrochemical sensor, wherein the meter comprises a processor for determining the concentration of an analyte in a sample, the processor comprising memory operably coupled to the processor, wherein the memory includes instructions stored thereon, the instructions comprising;

instructions for measuring a predetermined amount of a current decay for the current;

instructions for predicting a first total signal value for complete reaction of the analyte from the measured current decay;

instructions for determining a data collection endpoint, wherein the data collection endpoint is a predetermined percentage of the predicted first total signal value;

instructions for measuring current decay until the data collection endpoint;

instructions for calculating a second total signal value at the data collection endpoint; and

instructions for determining the concentration of an analyte based on the calculated second total signal value and the measured current decay until the data collection endpoint.

10. The analyte sensor system of claim 9, wherein the first total signal value is the sum of a measured signal value and an extrapolated signal.

11. The analyte sensor system of claim 10, wherein the memory further comprises instructions for predicting a total charge for complete electrolysis.

12. The analyte sensor system of claim 11, wherein the memory further comprises instructions for determining a predicted charge from an extrapolated linear current decay made at the data collection endpoint.

13. The analyte sensor system of claim 12, wherein the instructions for determining a predicted charge comprises integrating the extrapolated linear current decay made at the data collection endpoint and the measured current decay prior to the data collection endpoint to determine the total charge.

14. The analyte sensor system of claim 9, wherein the analyte sensor system further comprises an electrochemical sensor comprising a sample chamber, a working electrode and a counter electrode.

15. The analyte sensor system of claim 9, wherein the meter comprises coulometry.

16. The analyte sensor system of claim 9, wherein the meter comprises amperometry.

17. The analyte sensor system of claim 9, wherein the meter comprises potentiometry.