SYSTEMS APPROACH TO COMORBIDITY ASSESSMENT

• US 20110306845A1
• Filed: 06/15/2010
• Published: 12/15/2011
• Est. Priority Date: 06/15/2010
• Status: Active Grant

• Current Assignee: Flint Hills Scientific, LLC
• Original Assignee: Flint Hills Scientific, LLC
• Inventors: Osorio, Ivan
• Granted Patent: US 8,679,009 B2
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/16 Devices for psychotechnics using teaching or educational appliances G09B1/00 - G09B7/00; Testing reaction times ; Devices for evaluating the psychological state
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/417 the bone marrow
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence
• CPC Class Codes: A61B 5/4842 Monitoring progression or stage of a disease
• CPC Class Codes: A61B 5/4866 Evaluating metabolism A61B5/083 takes precedence
• CPC Class Codes: A61B 5/4884 inducing physiological or psychological stress, e.g. applications for stress testing
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

Methods, systems, and apparatus for assessing a state of a comorbidity associated with a primary disease are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of a body system of the patient that is a site of the comorbidity, based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.

Claims

1. A computer readable program storage unit encoded with instructions that, when executed by a computer, perform a method for assessing a comorbidity associated with a primary disease, comprising:

receiving at least one of an autonomic index, a neurologic index, a stress marker index, a psychiatric index, an endocrine index, a physical fitness index, or a quality of life index of a patient;

comparing the at least one index to at least one reference value associated with the at least one index;

assessing a state of a body system of the patient based on the comparing, wherein the body system comprises at least one of an autonomic system, a neurologic system, a psychiatric system, an endocrine system, or subsystems of the foregoing; and

providing an output relating to the assessment, wherein the output comprises at least one of body system stability, body system improvement, body system regression, or a finding that a state of the body system cannot be determined, wherein the body system is a site of the comorbidity.

2. The computer readable program storage unit of claim 1, wherein the method further comprises assessing a state of a second body system of the patient based on the comparing, wherein the second body system comprises at least one of an autonomic system, a neurologic system, a psychiatric system, an endocrine system, or subsystems of the foregoing, and the output comprises at least one of second body system stability, second body system improvement, second body system regression, or a finding that a state of the second body system cannot be determined, wherein the second body system is a site of a second comorbidity.

3. The computer readable program storage unit of claim 1, wherein the output comprises at least one of a magnitude of a change of an improvement, a magnitude of a change of a regression, a rate of change of an improvement, or a rate of change of a regression.

4. The computer readable program storage unit of claim 1, wherein the method further comprises assessing a state of the primary disease of the patient based on comparing the at least one index to the at least one reference value, wherein the output comprises disease stability, disease progression, disease regression, or a finding that a disease state cannot be determined.

5. The computer readable program storage unit of claim 4, wherein the output comprises identifying one or more comorbidities associated with the primary disease.

6. The computer readable program storage unit of claim 1, wherein the method further comprises providing a warning signal to the patient, a physician, or a caregiver if the output comprises disease progression.

7. The computer readable program storage unit of claim 6, wherein the warning signal is proportional to at least one of a magnitude of a change of a progression or a rate of change of a progression.

8. The computer readable program storage unit of claim 1, wherein the disease is epilepsy;

receiving comprises receiving at least one autonomic index selected from a cardiovascular parameter, a respiration parameter, a body temperature parameter, a skin resistance parameter, or two or more thereof; and

at least one neurologic index selected from an attention aptitude parameter, a responsiveness parameter, a memory parameter, a kinetic parameter, a cognitive aptitude parameter, or two or more thereof.

9. The computer readable program storage unit of claim 8, wherein receiving further comprises receiving at least one stress marker index selected from a cortisol parameter, a catecholamine parameter, or two or more thereof.

10. The computer readable program storage unit of claim 8, wherein the at least one autonomic index comprises at least one of a cardiovascular parameter or a respiratory parameter, and the at least one neurologic index comprises at least one of a responsiveness parameter or a kinetic parameter.

11. The computer readable program storage unit of claim 1, wherein the method further comprises forecasting a state of the body system, wherein the forecast comprises a body system stability, a body system improvement, a body system regression, or a finding that no forecast can be made.

12. The computer readable program storage unit of claim 1, wherein receiving comprises receiving a plurality of autonomic indices, neurologic indices, stress marker indices, psychiatric indices, endocrine indices, physical fitness indices, quality of life indices, or two or more thereof;

and

the at least one index comprises a weighted composite of the plurality of autonomic indices, neurologic indices, stress marker indices, psychiatric indices, endocrine indices, physical fitness indices, quality of life indices, or two or more thereof.

13. The computer readable program storage unit of claim 1, wherein the at least one reference value is based on the patient'"'"'s index value history or on normative data.

14. The computer readable program storage unit of claim 1, wherein the at least one index comprises a measure of central tendency, a measure of dimensionality, a measure of fractality, a measure of stationarity, a measure of long-range dependency, a measure of clustering, a distribution of measures of central tendency, a distribution of measures of dimensionality, a distribution of measures of fractality, a distribution of measures of stationarity, a distribution of measures of long-range dependency, a distribution of measures of clustering, or two or more thereof.