DIRECT CELLULAR ENERGY DELIVERY SYSTEM
First Claim
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1. A vesicle, comprising:
- (a) a phospholipid which is a stable vesicle former; and
(b) at least one unstable vesicle forming member, wherein the unstable vesicle forming member is selected from the group consisting of a PEG, a raft former, fusion protein, and a polar lipid having the structure of formula (I)
X-L-(Z)2
(I)wherein X is A or has a structure of formula (II)
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Abstract
A lipid vesicle comprising a phospholipid which is a stable vesicle former and at least one unstable vesicle forming member, wherein the unstable vesicle forming member is selected from the group consisting of a polar lipid which is not a stable vesicle former, a PEG, a raft former and a fusion protein is provided. The vesicle can further comprise a biomolecule, such as for example ATP. Methods of using the vesicle for delivery of biomolecules are also provided.
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Citations
53 Claims
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1. A vesicle, comprising:
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(a) a phospholipid which is a stable vesicle former; and (b) at least one unstable vesicle forming member, wherein the unstable vesicle forming member is selected from the group consisting of a PEG, a raft former, fusion protein, and a polar lipid having the structure of formula (I)
X-L-(Z)2
(I)wherein X is A or has a structure of formula (II) - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 39, 40, 41, 42, 43, 44, 45, 46, 51, 52, 53)
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29. A vesicle, comprising:
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a biomolecule; soy phosphatidylcholine; and DOTAP, wherein the vesicle is unilamellar. - View Dependent Claims (30, 31, 32, 33, 47, 48)
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34. A vesicle, comprising:
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a biomolecule; DOPC; and DOTAP, wherein the vesicle is unilamellar. - View Dependent Claims (35, 36, 37, 38, 49, 50)
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Specification