Compounds comprising 4-benzoylpiperidine as a Sigma-1-selective ligand
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Abstract
Bipiperidinyl compounds and salts thereof are disclosed. The compounds include high affinity ligands for σ1 receptors. Some compounds are also highly selective for σ1 receptor compared to σ2 receptor. Compounds can comprise radioisotopes, including 18F or 11C. Radiolabeled compounds can be used as probes for imaging distribution of σ1 receptor in a subject such as a human using positron emission tomography (PET) scanning.
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Citations
18 Claims
- 1. A compound of structure
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11. A method of imaging distribution of sigma-1 receptors in a subject, comprising:
Administering to a subject a radiolabeled compound of structure - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
Specification