Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds
First Claim
1. A composition comprising a concentrate of a planar ring structured organic compound and a heat stable solubilizing compound,wherein the concentration of said planar ring structured organic compound in said concentrate is greater than the saturation concentration of said planar ring structured organic compound in said heat stable solubilizing compound, andwherein said concentrate is not supersaturated.
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Abstract
The subject invention relates to novel soluble forms of planar ring structured organic compounds including flavonoids, and their production. The invention also includes the use of these novel formulations of planar ring structured organic compounds in the preparation of formulations and products. The invention also relates to a wide variety of applications of the formulations of the invention. The subject invention includes novel soluble forms and various formulations of flavonoids. Further, the invention includes novel methods of manufacturing the flavonoid formulations. The invention also relates to a wide variety of applications of the flavonoid formulations.
76 Citations
56 Claims
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1. A composition comprising a concentrate of a planar ring structured organic compound and a heat stable solubilizing compound,
wherein the concentration of said planar ring structured organic compound in said concentrate is greater than the saturation concentration of said planar ring structured organic compound in said heat stable solubilizing compound, and wherein said concentrate is not supersaturated.
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23. A composition comprising:
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i) a planar ring structured organic compound, and ii) a heat stable solubilizing compound, wherein said composition is formed by heating said planar ring structured organic compound in the presence of said heat stable solubilizing compound to a temperature such that said planar ring structured organic compound is dissolved in said heat stable solubilizing compound. - View Dependent Claims (24)
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28. A method of preparing a solubilized planar ring structured organic compound composition comprising:
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i) mixing said planar ring structured organic compound with a heat stable solubilizing compound to form a mixture, ii) heating said mixture resulting from step (i) to a temperature such that said planar ring structured organic compound is solubilized to form a concentrate, and iii) cooling said concentrate resulting from step (ii). - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method of increasing the solubility of a poorly soluble planar ring structured organic compound composition comprising:
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i) mixing said planar ring structured organic compound with a heat stable solubilizing compound to form a mixture, and ii) heating said mixture resulting from step (i) to a temperature such that the planar ring structured organic compound is solubilized to form a concentrate. - View Dependent Claims (40)
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52. A kit for forming a composition adapted for delivery of an active agent, said kit comprising
a first aliquot portion of a concentrate of planar ring structured organic active agent and a heat stable solubilizing compound, and a second aliquot portion of a carrier, wherein, when mixed, said first and second aliquot portions form a composition for delivery of said active agent contained therein.
Specification