CONTROLLED RELEASE COMPOSITIONS COMPRISING ANTI-CHOLINERGIC DRUGS
First Claim
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1. A controlled release composition comprising a plurality of anti-cholinergic drug-containing particles, the particles comprising:
- (a) a core comprising an anti-cholinergic drug;
(b) a first coating disposed over the core comprising at least one water-insoluble polymer; and
(c) a second coating disposed over the core comprising an enteric polymer optionally in combination with a water-insoluble polymer.
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Abstract
The present invention provides compositions comprising dicyclomine, or salts, and/or solvates and methods of making and using the compositions to treat intestinal hypermotility or Irritable Bowel Syndrome (IBS). The present invention also provides once-a-day orally disintegrating dosage forms comprising compositions of the present invention.
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Citations
42 Claims
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1. A controlled release composition comprising a plurality of anti-cholinergic drug-containing particles, the particles comprising:
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(a) a core comprising an anti-cholinergic drug; (b) a first coating disposed over the core comprising at least one water-insoluble polymer; and (c) a second coating disposed over the core comprising an enteric polymer optionally in combination with a water-insoluble polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A controlled release composition comprising a plurality of drug-containing particles, the particles comprising:
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(a) a core comprising a drug; (b) a first coating disposed over the core comprising at least one water-insoluble polymer; and (c) a second coating disposed over the core comprising an enteric polymer optionally in combination with a water-insoluble polymer (d) wherein the drug has a short plasma elimination half-life and requires frequent dosing to minimize adverse events.
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41. A controlled release composition a plurality of drug-containing particles, the particles comprising:
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(a) a core comprising the drug; (b) a first coating disposed over the core comprising a water-insoluble polymer; and (c) a second coating disposed over the first coating comprising an enteric polymer. - View Dependent Claims (42)
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Specification