PULSATILE RELEASE COMPOSITION OF THERAPEUTIC AGENT
First Claim
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1. A pulsatile release composition for oral administration comprising therapeutically active agent and pharmaceutically acceptable ingredients as a core unit and the said core unit is coated with pH sensitive graft copolymer having the formula 1
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Abstract
A pulsatile release composition which releases the content rapidly after a predetermined lag time comprising a drug containing a core, coated with a pH sensitive graft copolymer. The coating suppresses the drug release at acidic pH prevalent in the stomach and releases it either immediately or after a lag time in the intestinal region. Combinations of multiple numbers of coated and uncoated units provide a sequential pulsatile release of same or different therapeutic agents.
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Citations
30 Claims
- 1. A pulsatile release composition for oral administration comprising therapeutically active agent and pharmaceutically acceptable ingredients as a core unit and the said core unit is coated with pH sensitive graft copolymer having the formula 1
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Specification