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GENETIC ANALYSIS LOC WITH THERMAL BEND ACTUATED SURFACE TENSION VALVE

  • US 20110312602A1
  • Filed: 06/01/2011
  • Published: 12/22/2011
  • Est. Priority Date: 06/17/2010
  • Status: Abandoned Application
First Claim
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1. A lab-on-a-chip (LOC) device for genetic analysis comprising:

  • a supporting substrate;

    an array of probes for hybridization with target nucleic acid sequences to form probe-target hybrids;

    a channel for directing a flow of liquid containing the target nucleic acid sequences, the channel having an inlet, an outlet and a meniscus anchor between the inlet and the outlet such that the flow from the inlet towards the outlet stops at the meniscus anchor where the liquid forms a meniscus; and

    ,an actuator valve with a movable member for contacting the liquid, and an actuator for displacing the movable member from a quiescent position to an actuated position where the meniscus is extended into contact with a surface downstream of the meniscus anchor such that the liquid flow towards the outlet resumes.

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