GENETIC ANALYSIS LOC WITH REAGENT RESERVOIR
First Claim
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1. A LOC device for performing a genetic diagnostic assay, the LOC device comprising:
- a supporting substrate;
a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving a biological sample containing target nucleic acid sequences;
probes for hybridization with the target nucleic acid sequences to form probe-target hybrids;
a flow-path extending from the inlet to the probes; and
,a reagent reservoir containing a reagent for addition to the sample in the flow-path upstream of the probes.
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Abstract
A LOC device for performing a genetic diagnostic assay, the LOC device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving a biological sample containing target nucleic acid sequences, probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, a flow-path extending from the inlet to the probes, and, a reagent reservoir containing a reagent for addition to the sample in the flow-path upstream of the probes.
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Citations
20 Claims
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1. A LOC device for performing a genetic diagnostic assay, the LOC device comprising:
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a supporting substrate; a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving a biological sample containing target nucleic acid sequences; probes for hybridization with the target nucleic acid sequences to form probe-target hybrids; a flow-path extending from the inlet to the probes; and
,a reagent reservoir containing a reagent for addition to the sample in the flow-path upstream of the probes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification