Method and Apparatus for Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
First Claim
1. An apparatus for determining one or more properties of in vivo tissue, comprising:
- a. an illumination system adapted to produce light at a plurality of broadband wavelength ranges;
b. an optical probe adapted to receive broadband light from the illumination system and transmit the broadband light to in vivo tissue, and to receive light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof;
c. a calibration device which can be periodically placed in optical communication with the optical probe;
d. a spectrograph adapted to receive the light from the optical probe and produce a signal representative of spectral properties of the light;
e. an analysis system adapted to determine a property of the in vivo tissue from the spectral properties signal.
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Accused Products
Abstract
Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue from spectral information collected from the tissue. An illumination system provides light at a plurality of broadband ranges, which are communicated to an optical probe. The optical probe receives light from the illumination system and transmits it to in vivo tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe communicates the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties. A calibration device mounts such that it is periodically in optical communication with the optical probe.
22 Citations
20 Claims
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1. An apparatus for determining one or more properties of in vivo tissue, comprising:
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a. an illumination system adapted to produce light at a plurality of broadband wavelength ranges;
b. an optical probe adapted to receive broadband light from the illumination system and transmit the broadband light to in vivo tissue, and to receive light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof;
c. a calibration device which can be periodically placed in optical communication with the optical probe;
d. a spectrograph adapted to receive the light from the optical probe and produce a signal representative of spectral properties of the light;
e. an analysis system adapted to determine a property of the in vivo tissue from the spectral properties signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification