Infusion set with anesthetic compound

• US 20110313391A1
• Filed: 01/26/2010
• Published: 12/22/2011
• Est. Priority Date: 01/27/2009
• Status: Active Grant

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Horvath, Joshua, Knapp, Keith N. II
• Granted Patent: US 9,440,024 B2
• Time in Patent Office: Days
• US Class Current: 604/500
• CPC Class Codes: A61M 2005/1581 Right-angle needle-type devices
• CPC Class Codes: A61M 2205/0238 the material being a coating or protective layer
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: A61M 5/158 Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
• CPC Class Codes: A61M 5/422 Desensitising skin

Abstract

An exemplary insulin infusion set that further provides one or more set elements including the hub, hub adhesive, fluid line tubeset, connectors, catheters and insertion needles which can be impregnated with, coated with, or otherwise configured to contain and administer an anesthetic at the insertion and set placement locations to minimize user discomfort and the risk of complications associated with the use of infusion sets. To do so, the system and method provides steps for mixing at a step (22) at least two of a solvent, an anesthetic, and a lubricant, applying the mixed compound as a coating to at least one surface of the infusion set, patch pump, or an element thereof at a step (24), and then substantially removing the solvent after coating at a step (26) to provide at least one of an anesthetic layer and a lubricant layer upon the infusion set, patch pump, or an element thereof.

Claims

1. An infusion set configured to apply or administer an anesthetic, comprising:

a hub and catheter,

wherein at least one surface of said hub or catheter is provided with an anesthetic for release at a catheter insertion site.

2. An infusion set configured to apply or administer an anesthetic as claimed in claim 1, wherein said anesthetic is provided in a biocompatible polymer coating, such as a hydrogel, configured for release at a catheter insertion site over time.

3. An infusion set configured to apply or administer an anesthetic as claimed in claim 1, wherein said anesthetic is provided as a skin-contacting, adhesive layer disposed upon an outer surface of said hub for release at a catheter insertion site.

4. An infusion set configured to apply or administer an anesthetic as claimed in claim 1, wherein said anesthetic is provided as a layer disposed upon an inner surface of said hub or catheter for release at a catheter termination site within said insertion site.

5. An infusion set configured to apply or administer an anesthetic as claimed in claim 1, wherein said anesthetic is provided as a construction material of said hub or catheter for release at both a catheter insertion site and a catheter termination site within said insertion site.

6. An infusion set configured to apply or administer an anesthetic as claimed in claim 1, wherein said anesthetic comprises an anesthetic within a polydialkylsiloxane lubricant compound.

7. An infusion set configured to apply or administer an anesthetic as claimed in claim 1, wherein said anesthetic comprises at least one of amino esters, amino amides, and other anesthetic compounds.

8. An infusion set configured to apply or administer an anesthetic as claimed in claim 1, wherein said at least one surface of said hub or catheter is further provided with at least one of a lubricant material, an anti-microbial material, and an anti-inflammatory material with said anesthetic.

9. An infusion set configured to apply or administer an anesthetic as claimed in claim 1, wherein said infusion set further comprises a fluid tube set having at least one surface provided with at least one of a lubricant material, an anti-microbial material, an anti-inflammatory material, and an anesthetic.

10. A method of constructing an infusion set, patch pump, or element thereof, comprising the steps of:

mixing at least two of a solvent, an anesthetic, and a lubricant;

applying said mixture as a coating to at least one surface of an infusion set, patch pump, or element thereof; and

substantially removing said solvent after coating to provide at least one of an anesthetic layer and a lubricant layer upon said infusion set, patch pump, or element thereof.

11. A method of constructing an infusion set, patch pump, or element thereof, as recited in claim 10, wherein said step of mixing comprises mixing at least two of:

a polymer solvent;

an anesthetic compound, comprising at least one of amino esters, amino amides, and other anesthetic compounds;

a lubricant material;

an anti-microbial material; and

an anti-inflammatory material.

12. A method of constructing an infusion set, patch pump, or element thereof, as recited in claim 10, wherein said step of applying said mixture comprises at least one of:

a spraying step wherein said mixture is sprayed onto a surface of said infusion set, patch pump, or element thereof;

a dipping step wherein said infusion set, patch pump, or element thereof is dipped into said mixture; and

an inkjet printing step wherein said mixture is inkjet printed onto a surface of said infusion set, patch pump, or element thereof.

13. A method of constructing an infusion set, patch pump, or element thereof, as recited in claim 10, wherein said step of removing said solvent comprises:

an evaporation step for allowing said solvent to evaporate from said coated infusion set, patch pump, or element thereof.

14. A method of constructing an infusion set, patch pump, or element thereof, as recited in claim 10, wherein said at least one of said anesthetic layer and said lubricant layer is provided as a skin-contacting adhesive of said infusion set, patch pump, or element thereof configured to release said anesthetic at an infusion site.

15. A method of constructing an infusion set, patch pump, or element thereof, as recited in claim 10, wherein the at least one of said anesthetic layer and said lubricant layer is provided as an external coating of a catheter of said infusion set, patch pump, or element thereof configured to release said anesthetic at any point between an infusion site and a catheter termination site within said insertion site.

16. A method of constructing an infusion set, patch pump, or element thereof, as recited in claim 10, wherein the at least one of said anesthetic layer and said lubricant layer is provided as an internal coating of said infusion set, patch pump, or element thereof configured to release said anesthetic at a catheter termination site within said insertion site.

17. A method of constructing an infusion set, patch pump, or element thereof, as recited in claim 10, wherein the at least one of said anesthetic layer and said lubricant layer upon said infusion set, patch pump, or said element thereof is provided in a biocompatible polymer coating, such as a hydrogel, configured to release said anesthetic over a period of time.

18. A method of constructing an infusion set, patch pump, or element thereof, as recited in claim 10, wherein said anesthetic layer and said lubricant layer comprise an anesthetic within a polydialkylsiloxane lubricant compound.

19. A method of constructing an infusion set, patch pump, or element thereof, as recited in claim 18, wherein the step of mixing comprises:

mixing said polydialkylsiloxanes with an organic solvent comprising at least one of aliphatic hydrocarbons, methylene chloride, and other chlorinated solvents; and

dissolving said anesthetic in said solvent/polydialkylsiloxane mixture.

20. A method of constructing an infusion set, patch pump, or element thereof, as recited in claim 10, wherein the step of mixing comprises mixing said anesthetic with at least one of an aqueous and bioerodible polymer formulation.

21. A method of applying or administering an anesthetic at an infusion site, comprising the steps of:

providing at least one of a hub, catheter or cannula of an infusion set or patch pump with an anesthetic; and

affixing the infusion set or patch pump to the skin of a patient to release the anesthetic at an insertion site of said catheter or cannula.

22. A method of applying or administering an anesthetic at an infusion site as claimed in claim 21, wherein said anesthetic is provided in a biocompatible polymer coating, such as a hydrogel, configured for release at said insertion site over time.

23. A method of applying or administering an anesthetic at an infusion site as claimed in claim 21, wherein said anesthetic is provided as a skin-contacting, adhesive layer disposed upon an outer surface of said hub for release at said insertion site.

24. A method of applying or administering an anesthetic at an infusion site as claimed in claim 21, wherein said anesthetic is provided as a layer disposed upon an inner surface of said hub, catheter or cannula for release at a termination site within said insertion site.

25. A method of applying or administering an anesthetic at an infusion site as claimed in claim 21, wherein said anesthetic is provided as a construction material of said hub, catheter or cannula for release at both said insertion site and a termination site within said insertion site.

26. A method of applying or administering an anesthetic at an infusion site as claimed in claim 21, wherein said anesthetic comprises an anesthetic within a polydialkylsiloxane lubricant compound.

27. A method of applying or administering an anesthetic at an infusion site as claimed in claim 21, wherein said anesthetic comprises at least one of amino esters, amino amides, and other anesthetic compounds.

28. A method of applying or administering an anesthetic at an infusion site as claimed in claim 21, wherein said at least one surface of said hub, catheter or cannula is further provided with at least one of a lubricant material, an anti-microbial material, and an anti-inflammatory material with said anesthetic.