POROUS MEMBRANES FOR USE WITH IMPLANTABLE DEVICES
First Claim
1. A biointerface membrane suitable for implantation in a soft tissue, the membrane comprising:
- a first domain comprising a plurality of interconnected cavities and a solid portion, wherein the first domain has a depth of greater than one cavity in three dimensions substantially throughout an entirety of the first domain, and wherein the plurality of interconnected cavities and the solid portion of the first domain are dimensioned and arranged to redirect fibrous tissue contracture in vivo, thereby interfering with barrier cell layer formation within or around the first domain; and
a second domain, the second domain allowing passage of an analyte therethrough, wherein the second domain is resistant to cellular attachment and is impermeable to cells and cell processes.
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Accused Products
Abstract
A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.
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Citations
28 Claims
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1. A biointerface membrane suitable for implantation in a soft tissue, the membrane comprising:
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a first domain comprising a plurality of interconnected cavities and a solid portion, wherein the first domain has a depth of greater than one cavity in three dimensions substantially throughout an entirety of the first domain, and wherein the plurality of interconnected cavities and the solid portion of the first domain are dimensioned and arranged to redirect fibrous tissue contracture in vivo, thereby interfering with barrier cell layer formation within or around the first domain; and a second domain, the second domain allowing passage of an analyte therethrough, wherein the second domain is resistant to cellular attachment and is impermeable to cells and cell processes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A membrane suitable for implantation in a soft tissue, the membrane comprising:
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a first domain, the first domain comprising a plurality of interconnected cavities and a solid portion; and a second domain, the second domain allowing passage of an analyte therethrough, wherein the second domain is resistant to cellular attachment and is impermeable to cells and cell processes, wherein the plurality of interconnected cavities and the solid portion of the first domain are dimensioned and arranged to create a contractile force directed against the solid portion that counteracts a generally uniform downward fibrous tissue contracture caused by a foreign body response in vivo, thereby interfering with barrier cell layer formation proximal to the second domain. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of monitoring an analyte level, the method comprising the steps of:
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providing an implantable device configured to monitor an analyte level, the implantable device comprising a biointerface membrane, wherein the biointerface membrane comprises; a first domain, wherein the first domain comprises a plurality of interconnected cavities and a solid portion, wherein the plurality of interconnected cavities and the solid portion of the first domain are dimensioned and arranged to create a contractile force directed against the solid portion that counteracts a generally uniform downward fibrous tissue contracture caused by a foreign body response in vivo, thereby interfering with barrier cell layer formation within or around the first domain; and a second domain, the second domain allowing passage of an analyte therethrough, wherein the second domain is resistant to cellular attachment and is impermeable to cells and cell processes; implanting the implantable device in the host; and monitoring an analyte level. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28)
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Specification