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MHC Multimers in Cancer Vaccines and Immune Monitoring

  • US 20110318380A1
  • Filed: 10/01/2009
  • Published: 12/29/2011
  • Est. Priority Date: 10/01/2008
  • Status: Abandoned Application
First Claim
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1. A MHC monomer comprising a-b-P or a MHC multimer comprising (a-b-P)n, wherein n>

  • 1,wherein a and b together form a functional MHC protein capable of binding the antigenic peptide, P,wherein (a-b-P) is the MHC-peptide complex formed when the peptide P binds to the functional MHC protein,wherein each MHC peptide complex of a MHC multimer is associated with one or more multimerization domains and wherein P is a cancer antigenic peptide.

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