METHODS AND SYSTEMS FOR NON-INVASIVE, INTERNAL HEMORRHAGE DETECTION

• US 20110319724A1
• Filed: 10/30/2007
• Published: 12/29/2011
• Est. Priority Date: 10/30/2006
• Status: Abandoned Application

• Current Assignee: Paul G. Cox
• Original Assignee: Paul G. Cox
• Inventors: Cox, Paul G.
• Application Number:
  US12/665,811
• Publication Number:
  US 20110319724A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/726 using Wavelet transforms
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Methods and systems for detecting internal hemorrhaging in a person are provided. In an exemplary embodiment, one method includes the steps of measuring physiological conditions associated with the person and processing the measured physiological conditions using a probabilistic network to determine if the person has internal hemorrhaging. The method also includes the steps of determining the severity of any internal hemorrhaging by determining the amount of blood lost by the person and classifying this loss as non-specific, mild, moderate, and severe. The physiological measurements include an electrocardiogram, a photoplethysmogram, and oxygen saturation, respiratory, skin temperature, and blood pressure measurements. The probabilistic network included with one system determines whether there is internal hemorrhaging based on a number of factors including a physiological model, medical personnel inputs, transfer function, statistical, and spectral information, short and long term trends, and previous hemorrhage decisions.

Claims

1. A method for non-invasively detecting internal hemorrhaging in a person, comprising the steps of:

measuring a plurality of physiological conditions associated with a person to generate a plurality of physiological measurements; and

processing the plurality of physiological measurements using a real-time decision algorithm to determine if the person has internal hemorrhaging and, if so, internal hemorrhaging severity.

2. The method of claim 1, wherein the plurality of physiological measurements includes an electrocardiogram, a photoplethysmogram, an oxygen saturation measurement, a respiratory measurement, a skin temperature measurement, a blood pressure measurement, and a Glasgow coma score measurement.

3. The method of claim 1, wherein the step of determining internal hemorrhaging severity includes the step of determining how much blood has been lost by the person.

4. The method of claim 3, wherein the real-time decision algorithm classifies blood loss by the person as non-specific blood loss, mild blood loss, moderate blood loss, or severe blood loss.

5. The method of claim 1, wherein:

the processing step includes a pre-processing step and a feature extraction step;

the pre-processing step includes the step of filtering the plurality of physiological measurements to generate a plurality of filtered physiological measurements; and

the feature extraction step includes the step of extracting statistical, spectral, and temporal features from the plurality of filtered physiological measurements.

6. The method of claim 5, wherein the step of filtering the plurality of physiological measurements includes the step of filtering the plurality of physiological measurements using Fourier and wavelet filtering.

7. The method of claim 1, wherein:

the processing step includes a feature extraction step;

the feature extraction step includes the step of extracting statistical features, frequency features, trend features, transfer function features, non-linear features, and physiological features; and

the real-time decision algorithm processes the statistical, frequency, trend, transfer function, non-linear, and physiological features.

8. The method of claim 1, wherein the processing step includes the step of calculating correlations between the plurality of physiological measurements.

9. A system for detecting and estimating internal hemorrhaging severity in a person, comprising:

a plurality of physiological sensors for measuring physiological conditions associated with a person; and

a real-time probabilistic network connected to the plurality of physiological sensors for detecting if the person has internal hemorrhaging and estimating internal hemorrhaging severity based on the measured physiological conditions associated with the person.

10. The system of claim 9, wherein the plurality of physiological sensors includes an electrocardiogram, a photoplethysmogram, an oxygen saturation sensor, a respiratory sensor, a skin temperature sensor, and a blood pressure sensor.

11. The system of claim 9, wherein the real-time probabilistic network determines how much blood has been lost by the person.

12. The system of claim 11, wherein the real-time probabilistic network classifies the amount of blood lost by the person as non-specific blood loss, mild blood loss, moderate blood loss, or severe blood loss.

13. The system of claim 9, wherein:

the real-time probabilistic network performs pre-processing, the pre-processing comprising filtering the plurality of physiological measurements to generate a plurality of filtered physiological measurements, and feature extraction, the feature extraction comprising extracting statistical, spectral, and temporal features from the plurality of filtered physiological measurements, of the measured physiological conditions.

14. The system of claim 13, wherein filtering the plurality of physiological measurements includes filtering the plurality of physiological measurements using Fourier and wavelet filtering.

15. The system of claim 9, wherein:

the real-time probabilistic network performs feature extraction, the feature extraction comprising extracting statistical features, frequency features, trend features, transfer function features, non-linear features, and physiological features; and

the real-time probabilistic network processes the extracted statistical, frequency, trend, transfer function, non-linear, and physiological features.

16. A system for detecting and estimating internal hemorrhaging severity in a person, comprising:

a plurality of vital sign sensors operative to take physiological measurements from the person;

a physiological modeling module, operative to receive the physiological measurements from the plurality of vital sign sensors;

a pre-processing module and filtering module, operative to receive the physiological measurements from the plurality of vital sign sensors;

a feature extraction module, operative to receive the filtered physiological measurements from the pre-processing and filtering module; and

a decision support algorithm, the decision support algorithm comprising a real-time probabilistic network for detecting and estimating the severity of internal hemorrhaging in the person based on the outputs of the physiological modeling module, the pre-processing and filtering module, and the feature extraction module.

17. The system of claim 16, wherein the plurality of vital sign sensors comprise:

an electrocardiogram, a blood pressure sensor, a photoplethysmogram, an oxygen saturation sensor, a respiratory sensor, and a skin temperature sensor.

18. The system of claim 16, wherein the physiological modeling module is based on a trivariate model.

19. The system of claim 16, wherein the physiological modeling module is based on a cardiovascular short-term regulation model.

20. The system of claim 16, wherein the pre-processing and filtering module filters the physiological measurements from the vital sign sensors to generate a plurality of filtered physiological measurements using at least one of Fourier and wavelet filtering.

21. The system of claim 16, wherein the feature extraction module extracts statistical, spectral, transfer function, long-term trend, and short-term trend features from the plurality of filtered physiological measurements.