Red Light Implants for Treating Postpartum Depression

• US 20110319878A1
• Filed: 06/24/2010
• Published: 12/29/2011
• Est. Priority Date: 06/24/2010
• Status: Abandoned Application

• Current Assignee: Depuy Synthes Products Incorporated (Johnson & Johnson)
• Original Assignee: Depuy Synthes Products Incorporated (Johnson & Johnson)
• Inventors: DiMauro, Thomas M., Fisher, Michael A.
• Application Number:
  US12/822,803
• Publication Number:
  US 20110319878A1
• Time in Patent Office: Days
• US Class Current: 606/14
• CPC Class Codes: A61N 2005/0612 using probes penetrating tissue; interstitial probes
• CPC Class Codes: A61N 2005/0647 the applicator adapted to be worn on the head
• CPC Class Codes: A61N 2005/0651 Diodes
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 2005/0662 Visible light
• CPC Class Codes: A61N 5/0618 Psychological treatment
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue

Abstract

Irradiating an orbitofrontal cortex of a patient having postpartum depression with red/near infrared light in order to increase metabolism, bcl-2 and BDNF in the patient'"'"'s orbitofrontal cortex.

Claims

1. A method of treating depression in a patient, comprising the steps of:

a) inserting a device comprising a red/NIR light LED into a patient'"'"'s skull,

b) activating the LED to irradiate at least a portion of an orbitofrontal cortex.

2. The method of claim 1 wherein the patient has post-partum depression.

3. The method of claim 1 wherein the device is inserted into an upper portion of a sphenoid bone in the patient and remains outside of a dura.

5. The method of claim 1 wherein the device is inserted between the patient'"'"'s skull and a patient'"'"'s brain.

6. The method of claim 1 wherein the insertion step is carried out through a temporalis muscle.

7. The method of claim 1 wherein the activation step includes transdermal transmission of Rf energy.

8. The method of claim 1 wherein the device includes a capacitor.

9. The method of claim 1 wherein the activation of the LED further irradiates an amygdala.

10. The method of claim 1 wherein the activation of the LED further irradiates a temporal pole.

11. The method of claim 1 wherein the orbitofrontal cortex is irradiated bilaterally.

12. The method of claim 1 wherein the orbitofrontal cortex is irradiated unilaterally.

13. The method of claim 1 wherein the insertion step include inserting the device through an occipital opening behind an ear of the patient..

14. The method of claim 1 wherein the insertion step includes inserting the device through a parietal opening anterior to a coronal suture.

15. The method of claim 1 wherein the insertion step includes intranasally inserting the device.

16. The method of claim 1 wherein the intranasal insertion step includes inserting the device into a maxillary sinus.

17. The method of claim 1 wherein the insertion step includes inserting the device through an orbitozygomatic approach.

18. The method of claim 1 wherein the irradiation results in an increase in metabolism in the orbitofrontal cortex.

19. The method of claim 1 wherein the irradiation results in an increase in cytochrome c oxidase in the orbitofrontal cortex.

20. The method of claim 1 wherein the irradiation results in an increase in BDNF in the orbitofrontal cortex.

21. The method of claim 1 wherein the irradiation results in an increase in bcl-2 in the orbitofrontal cortex.

4. The method of claim 4 wherein the upper portion of the sphenoid bone is filled with a translucent synthetic material.

22. A light-emitting implant for treating a brain disorder, the implant substantially encapsulated within a hermetically-sealed housing which is inert to body fluids, the implant comprising:

a) a coil adapted to function as a secondary winding of a transformer and to be disposed in a modulated, alternating magnetic field,

b) a red/NIR LED,

c) an electronic controller,

d) a capacitor for storing power for the LED and the electronic controller,

e) a charge controller for controllably charging the capacitor means from the alternating magnetic field,

wherein the electronic controller controls discharge of the capacitor to provide irradiation through the LED, and further provides control of at least one of the duration and the current in accordance with the modulation of the alternating magnetic field.

23. A light-emitting implant for treating a brain disorder, the implant comprising:

a) a planar array of red/NIR LEDs,

b) a power source in electrical connection with the LEDs,

24. A light-emitting implant for treating a brain disorder, the implant comprising:

a) a red/NIR LED,

b) a power source in electrical connection with the LED,

c) a non-linear wave guide connected to the LED.