PORTABLE SAMPLE ANALYZER CARTRIDGE
First Claim
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1. A disposable analysis cartridge capable of performing at least part of a blood sample measurement, comprising:
- two or more flow cytometry analysis channels including a first flow cytometry analysis channel and a second flow cytometry analysis channel;
the first flow cytometry analysis channel having a first intersecting region that receives at least part of the blood sample as well as a sheath fluid and hydrodynamically focuses the at least part of the blood sample into a first core stream surrounded by the sheath fluid, the first flow cytometry analysis channel further including a first optical window to support flow cytometric measurements of the first core stream;
the second flow cytometry analysis channel having a second intersecting region that receives at least part of the blood sample as well as a sheath fluid and hydrodynamically focuses the at least part of the blood sample into a second core stream surrounded by the sheath fluid, the second flow cytometry analysis channel further including a second optical window to support flow cytometric measurements of the second core stream; and
a fluid director for directing flow of the blood sample to the first and second flow cytometry analysis channels.
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Abstract
A sample analyzer cartridge for use at a point of care of a patient such as in a doctor'"'"'s office, in the home, or elsewhere in the field. By providing a removable and/or disposable cartridge with all of the needed reagents and/or fluids, the sample analyzer can be reliably used outside of the laboratory environment, with little or no specialized training.
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Citations
30 Claims
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1. A disposable analysis cartridge capable of performing at least part of a blood sample measurement, comprising:
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two or more flow cytometry analysis channels including a first flow cytometry analysis channel and a second flow cytometry analysis channel; the first flow cytometry analysis channel having a first intersecting region that receives at least part of the blood sample as well as a sheath fluid and hydrodynamically focuses the at least part of the blood sample into a first core stream surrounded by the sheath fluid, the first flow cytometry analysis channel further including a first optical window to support flow cytometric measurements of the first core stream; the second flow cytometry analysis channel having a second intersecting region that receives at least part of the blood sample as well as a sheath fluid and hydrodynamically focuses the at least part of the blood sample into a second core stream surrounded by the sheath fluid, the second flow cytometry analysis channel further including a second optical window to support flow cytometric measurements of the second core stream; and a fluid director for directing flow of the blood sample to the first and second flow cytometry analysis channels. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. The disposable analysis cartridge of claim I further comprising an extinction channel that is configured to support optical extinction measurements.
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29. A disposable analysis cartridge capable of performing at least part of a blood sample measurement, comprising:
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two or more separate flow cytometry analysis channels, each of the two or more separate flow cytometry analysis channels having means for hydrodynamically focusing a sample and means for supporting flow cytometric measurements of the focused sample; and fluid directing means for directing flow of a blood sample to at least two of the two or more flow cytometry analysis channels.
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30. A disposable analysis cartridge capable of performing at least part of a blood sample measurement, comprising:
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two or more reagent storage reservoirs, a first one for storing a lysing reagent and a second one for storing a sphering reagent; a lysing on the fly channel in fluid communication with the first one of the reagent storage reservoirs; a sphering on the fly channel in fluid communication with the second one of the reagent storage reservoirs; a first flow cytometry analysis channel structured to hydrodynamically focus a blood sample and to support optical light scattering measurements, the first flow cytometry analysis channel in fluid communication with and downstream of the lysing on the fly channel; and a second flow cytometry analysis channel structured to hydrodynamically focus a blood sample and to support optical light scattering measurements, the second flow cytometry analysis channel in fluid communication with and downstream of the sphering on the fly channel.
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Specification