SELF-ENCODING SENSOR WITH MICROSPHERES
First Claim
Patent Images
1. A method of detecting an analyte, said method comprising:
- (a) providing an array comprising a population of sensor elements at a density of at least 20,000 sensor elements per 1 mm2, said population of sensor elements comprising different subpopulations of redundant sensor elements;
(b) providing said array with an analyte under conditions wherein said analyte binds to redundant sensor elements in at least one subpopulation of sensor elements, thereby producing signals at separate redundant sensor elements;
(c) detecting said signals from separate redundant sensor elements in said at least one subpopulation of redundant sensor elements; and
(d) combining signals detected from said separate redundant sensor elements wherein said signals are indicative of said analyte, and wherein said signals comprise like signals selected from the group consisting of optical signals, data representations of optical signals, non-optical signals and data representations of non-optical signals.
2 Assignments
0 Petitions
Accused Products
Abstract
Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.
-
Citations
28 Claims
-
1. A method of detecting an analyte, said method comprising:
-
(a) providing an array comprising a population of sensor elements at a density of at least 20,000 sensor elements per 1 mm2, said population of sensor elements comprising different subpopulations of redundant sensor elements; (b) providing said array with an analyte under conditions wherein said analyte binds to redundant sensor elements in at least one subpopulation of sensor elements, thereby producing signals at separate redundant sensor elements; (c) detecting said signals from separate redundant sensor elements in said at least one subpopulation of redundant sensor elements; and (d) combining signals detected from said separate redundant sensor elements wherein said signals are indicative of said analyte, and wherein said signals comprise like signals selected from the group consisting of optical signals, data representations of optical signals, non-optical signals and data representations of non-optical signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
-
-
18. A method of detecting signals produced at sensor elements of an array, said method comprising:
-
(a) providing an array comprising a population of sensor elements at a density of at least 20,000 sensor elements per 1 mm2, said population of sensor elements comprising different subpopulations of redundant sensor elements, each of said redundant sensor elements comprising a well that includes not more than one bead having nucleic acids attached thereto; (b) providing an analyte to the array so as to produce signals at separate redundant sensor elements in at least one subpopulation of sensor elements; (c) detecting said signals from separate redundant sensor elements in at least one subpopulation of redundant sensor elements; and (d) combining signals detected from said separate redundant sensor elements wherein said signals comprise like signals selected from the group consisting of optical signals, data representations of optical signals, non-optical signals and data representations of non-optical signals. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
-
Specification