PHENYLCYCLOPROPYLAMINE DERIVATIVES AND THEIR MEDICAL USE
First Claim
Patent Images
1. A compound of Formula I for use in treating or preventing cancer:
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to phenylcyclopropylamine derivatives. In particular, pharmaceutical compositions comprising phenylcyclopropylamine derivatives are provided. The compounds of this invention can, inter alia, be used for the treatment and the prevention of cancer as well as neurodegenerative diseases or disorders.
51 Citations
35 Claims
- 1. A compound of Formula I for use in treating or preventing cancer:
- 14. A compound of Formula I:
-
31. (canceled)
-
35. A method of identifying LSD1 selective and LSD1/MAO-B dual inhibitors comprising determining the ability of a test compound to inhibit LSD1, MAO-A, and MAO-B wherein a LSD1 selective inhibitor is identified when the test compound inhibits LSD1 to a greater extent than MAO-A and MAO-B and wherein a LSD1/MAO-B dual inhibitor is identified when the test compound inhibits LSD1 and MAO-B to a greater extent than it inhibits MAO-A wherein said test compound is compound of Formula I:
Specification