BIOARTIFICIAL LIVER
First Claim
Patent Images
1. A bioartificial liver device comprising a reservoir chamber configured to house hepatocyte spheroids, wherein said reservoir chamber comprises a mixing chamber and a settling volume chamber, wherein said mixing chamber is separated from said settling volume chamber by a funnel, and wherein said mixing chamber is in fluid communication with said settling volume chamber via at least one opening defined in said funnel.
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Abstract
This document provides bioartificial liver (BAL) devices. Methods for making and using BAL devices also are provided.
24 Citations
34 Claims
- 1. A bioartificial liver device comprising a reservoir chamber configured to house hepatocyte spheroids, wherein said reservoir chamber comprises a mixing chamber and a settling volume chamber, wherein said mixing chamber is separated from said settling volume chamber by a funnel, and wherein said mixing chamber is in fluid communication with said settling volume chamber via at least one opening defined in said funnel.
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11. A bioartificial liver device, comprising:
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a plurality of cell containers for forming hepatocyte spheroids; a multi-shelf rocking device configured to rock said plurality of cell containers; and a reservoir chamber configured to house said hepatocyte spheroids after being formed in said plurality of cell containers. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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- 19. A bioartificial liver device comprising a reservoir chamber configured to house hepatocyte spheroids, wherein said reservoir chamber comprises a screen or mesh configured to allow bi-directional fluid flow.
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27. A bioartificial liver device, comprising:
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an albumin dialysis system; and a reservoir chamber in fluid communication with said albumin dialysis system, said reservoir chamber being configured to house hepatocyte spheroids. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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Specification