SELECTION BY COMPARTMENTALISED SCREENING
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Abstract
The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, by compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsules; and identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
140 Citations
129 Claims
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1-108. -108. (canceled)
- 109. An emulsion library comprising a plurality of droplets within an immiscible fluorocarbon oil, wherein each droplet comprises an aqueous phase fluid and a single member of a repertoire of compounds.
- 120. An emulsion library comprising a plurality of droplets within an immiscible fluorocarbon oil, wherein each droplet comprises an aqueous phase fluid and a subset of a repertoire of compounds.
- 125. An emulsion library comprising a plurality of droplets within an immiscible fluid, wherein each droplet comprises an aqueous phase fluid and a single member of a repertoire of compounds, and the droplets are formed by dispersion in a stream of the immiscible fluid in a microfluidic channel.
Specification