Method of stimulating the motility of the gastrointestinal system using ipamorelin

• US 20120010157A1
• Filed: 09/16/2011
• Published: 01/12/2012
• Est. Priority Date: 08/12/2004
• Status: Abandoned Application

• Current Assignee: Helsinn Therapeutics (U.S.), Inc (Helsinn Healthcare SA)
• Original Assignee: Helsinn Therapeutics (U.S.), Inc (Helsinn Healthcare SA)
• Inventors: Polvino, William J., Nelson, Richard, Mann, William R.
• Application Number:
  US13/234,248
• Publication Number:
  US 20120010157A1
• Time in Patent Office: Days
• US Class Current: 514/21.8
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/33 Heterocyclic compounds
• CPC Class Codes: A61K 31/417 Imidazole-alkylamines, e.g. histamine, phentolamine
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61K 38/08 Peptides having 5 to 11 amino acids A61K38/043 - A61K38/046 take precedence
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system

Abstract

The present invention provides a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders, diseases, conditions, or drug- or surgery-induced dysfunction) of the gastrointestinal system, by administering to the subject a ghrelin mimetic, or pharmaceutically acceptable salt thereof. The invention also provides a method of treating a gastrointestinal malady by co-administering a ghrelin mimetic with a laxative, a H₂ receptor antagonist, a serotonin receptor agonist, pure or mixed, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof.

Claims

1-18. -18. (canceled)

19. A method of treating gastroparesis in a human subject in need thereof comprising administering to said subject a therapeutically effective amount of a compound represented by the structural Formula I:

20. The method of claim 19, wherein the subject is using an opioid for post-surgical pain management.

21. The method of claim 19, wherein the subject is using an opioid for chronic pain management.

22. The method of claim 21, wherein the opioid is selected from the group consisting of morphine, codeine, oxycodone, hydromorphone, hydrocodone, methadone, and fentanyl.

23. The method of claim 19, wherein the compound is administered in a manner in order to achieve an effective plasma concentration.

26. The method of claim 19, consisting essentially of administering said compound or a pharmaceutically acceptable salt thereof.

28. The method of claim 19, wherein said administration is via injection.

24. A method of stimulating the motility of the gastrointestinal system in a human subject suffering from gastroparesis comprising administering to said subject a therapeutically effective amount of a compound represented by the structural Formula I:

25. The method of claim 24, wherein the compound is administered in a manner to achieve an effective plasma concentration.

27. The method of claim 24, consisting essentially of administering said compound or a pharmaceutically acceptable salt thereof.

29. The method of claim 24, wherein said administration is via injection.