PYRROLO[2,3-b]PYRIDIN-4-YL-AMINES AND PYRROLO[2,3-b]PYRIMIDIN-5-YL-AMINES AS JANUS KINASE INHIBITORS
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Abstract
The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
88 Citations
60 Claims
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1-37. -37. (canceled)
- 38. A method of inhibiting an activity of JAK2 comprising contacting said JAK2 with a compound of Formula I:
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39. (canceled)
- 41. A method of treating a disease in a patient, wherein said disease is associated with JAK activity, comprising administering to said patient a therapeutically effective amount of a compound of Formula I:
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47-54. -54. (canceled)
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55. A method of treating a skin disorder in a patient comprising topically administering to said patient a therapeutically effective amount of a compound of
Formula II:
Specification