DISCRIMINATION OF CHEYNE-STOKES BREATHING PATTERNS BY USE OF OXIMETRY SIGNALS
First Claim
1. A method for indicating the presence of Cheyne-Stokes respiration from blood oxygen saturation levels measured by an oximetry signal comprising:
- identifying and removing artifactual oximetry periods from the oximetry signal to produce a second signal; and
with a processor, determining a mean length of contiguous periods of resaturation in the second signal and generating a positive indication of Cheyne-Stokes respiration based on an extent of the determined mean length.
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Accused Products
Abstract
Methods and apparatus provide Cheyne-Stokes respiration (“CSR”) detection based on a blood gas measurements such as oximetry. In some embodiments, a duration, such as a mean duration of contiguous periods of changing saturation or re-saturation occurring in an epoch taken from a processed oximetry signal, is determined. An occurrence of CSR may be detected from a comparison of the duration and a threshold derived to differentiate saturation changes due to CSR respiration and saturation changes due to obstructive sleep apnea. The threshold may be a discriminant function derived as a classifier by an automated training method. The discriminant function may be further implemented to characterize the epoch for CSR based on a frequency analysis of the oximetry data. Distance from the discriminant function may be utilized to generate probability values for the CSR detection.
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Citations
36 Claims
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1. A method for indicating the presence of Cheyne-Stokes respiration from blood oxygen saturation levels measured by an oximetry signal comprising:
- identifying and removing artifactual oximetry periods from the oximetry signal to produce a second signal; and
with a processor, determining a mean length of contiguous periods of resaturation in the second signal and generating a positive indication of Cheyne-Stokes respiration based on an extent of the determined mean length. - View Dependent Claims (2, 3, 4, 5, 6)
- identifying and removing artifactual oximetry periods from the oximetry signal to produce a second signal; and
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7. A method for indicating the presence of Cheyne-Stokes respiration from blood oxygen saturation levels measured by an oximetry signal and a ventilation flow signal comprising:
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determining with a processor a delay of blood oxygen saturation level data compared to ventilation flow level data having either an apnea or hypopnea and an hyperpnoea; and generating a positive indication of Cheyne-Stokes respiration for determined delays above a predetermined threshold.
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8. A method for training a classifier to discriminate Cheyne-Stokes respiration from blood oxygen saturation levels measured by an oximetry signal comprising:
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pre-classifying polysomnographic data to obtain non-overlapping epochs each with a specified class of dominating event; with a processor, segmenting oximetry and flow recordings into non-overlapping epochs of data having a predetermined length of time; and forming a decision boundary with a processor to discriminate Cheyne-Stokes respiration and non-Cheyne-Stokes respiration classes of events with the epochs. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A device for detecting the presence of Cheyne-Stokes respiration from an oximetry signal and a ventilation flow signal, wherein said device identifies and removes artifactal oximetry periods from the oximetry signal to produce an second signal;
- and wherein the device determines the mean length of contiguous periods of re-saturation in the second signal and returns a positive indication of Cheyne-Stokes respiration, if said mean length is greater than a predetermined threshold.
- View Dependent Claims (16, 17)
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18. A computer implemented method of detecting an occurrence of Cheyne-Stokes respiration with one or more programmed processors comprising:
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accessing blood gas data representing a measured blood gas signal; determining a duration of one or more contiguous periods of changing saturation of a blood gas from the blood gas data; detecting the occurrence of Cheyne-Stokes respiration from a comparison of the determined duration and a threshold derived to differentiate saturation changes due to Cheyne-Stokes respiration and saturation changes due to obstructive sleep apnea. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25)
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26. An apparatus to detect an occurrence of Cheyne-Stokes breathing, the apparatus comprising:
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a memory for blood gas data representing a measured blood gas signal; a processor coupled with the memory, the processor being configured (a) to determine a duration of one or more contiguous periods of changing saturation of a blood gas from the blood gas data and (b) to detect an occurrence of Cheyne-Stokes respiration from a comparison of the determined duration and a threshold derived to differentiate saturation changes due to Cheyne-Stokes respiration and saturation changes due to obstructive sleep apnea. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33)
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34. An apparatus for indicating the presence of Cheyne-Stokes respiration from blood oxygen saturation levels measured by an oximetry signal comprising:
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means for identifying and removing artifactual oximetry periods from the oximetry signal to produce a second signal; and means for determining a mean length of contiguous periods of re-saturation in the second signal and generating a positive indication of Cheyne-Stokes respiration based on an extent of the determined mean length.
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35. An apparatus for indicating the presence of Cheyne-Stokes respiration from blood oxygen saturation levels measured by an oximetry signal and a ventilation flow signal comprising:
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means for determining a delay of blood oxygen saturation level data compared to ventilation flow level data having either an apnea or hypopnea and an hyperpnoea; and means for generating a positive indication of Cheyne-Stokes respiration for determined delays above a predetermined threshold.
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36. An apparatus for detecting an occurrence of Cheyne-Stokes respiration comprising:
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means for accessing blood gas data representing a measured blood gas signal; means for determining a duration of one or more contiguous periods of changing saturation of a blood gas from the blood gas data; means for detecting the occurrence of Cheyne-Stokes respiration from a comparison of the determined duration and a threshold derived to differentiate saturation changes due to Cheyne-Stokes respiration and saturation changes due to obstructive sleep apnea.
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Specification