System for Respiration Data Processing and Characterization

• US 20120016251A1
• Filed: 03/08/2011
• Published: 01/19/2012
• Est. Priority Date: 07/15/2010
• Status: Abandoned Application

• Current Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Original Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Inventors: Zhang, Hongxuan, Koertge, Detlef W., Wade, Harold James, Steibel, Dennis Jr.
• Application Number:
  US13/042,806
• Publication Number:
  US 20120016251A1
• Time in Patent Office: Days
• US Class Current: 600/532
• CPC Class Codes: A61B 5/082 Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath A61B5/083, A61B5/091 take precedence
• CPC Class Codes: A61B 5/0836 Measuring rate of CO2 production
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

A system for respiration or cardiac condition characterization and abnormality detection includes an interface that receives data representing a signal indicating concentration of carbon dioxide in patient gases over multiple signal cycles. A signal processor uses the received data in determining multiple amplitude related characteristic values. A comparator compares at least one of the amplitude related characteristic values or a value derived from the amplitude related characteristic values, with a threshold value to provide a comparison indicator. A patient monitor in response to the comparison indicator indicating an amplitude related characteristic value or a value derived from the amplitude related characteristic values, exceeds the threshold value, generates an alert message associated with the threshold.

Claims

1. A system for respiration or cardiac condition characterization and abnormality detection, comprising:

an interface for receiving data representing a signal indicating concentration of carbon dioxide in patient gases over a plurality of signal cycles;

a signal processor for using the received data in determining a plurality of amplitude related characteristic values comprising at least two of,

(a) a magnitude of an amplitude of a baseline of said signal,

(b) a magnitude of an amplitude at an end of early exhalation of said signal,

(c) a magnitude of an amplitude of a start of the exhalation plateau of said signal,

(d) a magnitude of an amplitude of an end tidal point of said signal and

(e) a magnitude of an amplitude at an end of inhalation point of said signal;

a comparator for comparing at least one of said amplitude related characteristic values or a value derived from said amplitude related characteristic values, with a threshold value to provide a comparison indicator; and

a patient monitor for in response to said comparison indicator indicating an amplitude related characteristic value or a value derived from said amplitude related characteristic values, exceeds the threshold value, generating an alert message associated with the threshold.

2. A system according to claim 1, wherein

said value derived from said amplitude related characteristic values comprises a ratio of at least two of said amplitude related characteristic values.

3. A system according to claim 1, wherein

said signal processor determines a time associated with at least two of said plurality of amplitude related characteristic values.

4. A system according to claim 1, wherein

said signal processor uses the received data in determining

(i) a time duration of an inhalation process and

(ii) a time duration of an exhalation process.

5. A system according to claim 1, wherein

said signal processor calculates a ratio including said time duration of said inhalation process and said time duration of said exhalation process.

6. A system according to claim 1, wherein

said signal indicates concentration of carbon dioxide in at least one of, (a) respiratory gases and (b) intra-cardiac gases.

7. A system according to claim 1, wherein

said signal processor employs a heart cycle synchronization signal in determining said amplitude related characteristic values.

8. A system according to claim 1, wherein

said signal processor provides said value derived from said amplitude related characteristic values by averaging over a plurality of cycles.

9. A system according to claim 1, wherein

said signal processor provides said value derived from said amplitude related characteristic values by determining a standard deviation or variance over a plurality of cycles.

10. A system according to claim 1, wherein

said signal processor provides said value derived from said amplitude related characteristic values by determining a ratio of an average to a standard deviation or variance of values.

11. A system according to claim 1, including

a repository of predetermined mapping information, associating ranges of said amplitude related characteristic values or a value derived from said amplitude related characteristic values, with corresponding medical conditions and

said comparator compares said amplitude related characteristic values or a value derived from said amplitude related characteristic values, with said ranges to provide a comparison indicator identifying a medical condition and

said patient monitor generates an alert message identifying said medical condition.

12. A system according to claim 11, wherein

said predetermined mapping information associates ranges of said amplitude related characteristic values or a value derived from said amplitude related characteristic values, with particular patient demographic characteristics and with corresponding medical conditions and said system uses patient demographic data including at least one of, age weight, gender and height in comparing said amplitude related characteristic values or a value derived from said amplitude related characteristic values, with said ranges and generating an alert message indicating a potential medical condition.

13. A system according to claim 1, wherein

said signal cycles are (a) respiratory cycles if respiratory carbon dioxide data is being processed and (b) cardiac cycles if cardiac carbon dioxide data is being processed.

14. A system according to claim 1, wherein

said received data comprises received sampled data.

15. A system for respiration or cardiac condition characterization and abnormality detection, comprising:

an interface for receiving data representing a signal indicating concentration of carbon dioxide in patient gases over a plurality of signal cycles;

a signal processor for using the received data in determining at least one frequency related characteristic value comprising at least one of,

(a) a dominant frequency of said signal and

(b) a value derived by integration of the square of frequency over a bandwidth of said signal and comparing the frequency related characteristic value with a corresponding normal derived value; and

a patient monitor for generating an alert message associated with the comparison, in response to the comparison.

16. A system according to claim 15, wherein

said signal processor generates a ratio of said frequency related characteristic value to said corresponding normal derived value to compare values and

said patient monitor generates said alert message in response to the ratio exceeding a predetermined threshold.

17. A system according to claim 16, wherein

said corresponding normal derived value is at least one of, (a) a corresponding normal value for the patient concerned determined on a previous occasion and (b) a corresponding normal value for a population of patients having similar demographic characteristics as the patient.

18. A system for respiration or cardiac condition characterization and abnormality detection, comprising:

an interface for receiving sampled data representing a signal indicating concentration of carbon dioxide in patient gases over a plurality of cardiac cycles;

a signal processor for using the received sampled data in determining a mutual correspondence measure of the signal and a corresponding signal determined for the patient on a previous occasion; and

a patient monitor for generating an alert message associated with the comparison, in response to the comparison.

19. A system according to claim 18, wherein said mutual correspondence measure is derived using a function of the form,