INTEGRATED ANALYTICAL SYSTEM AND METHOD
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Accused Products
Abstract
An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
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Citations
45 Claims
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1-6. -6. (canceled)
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7. A device comprising an array of optode elements, each optode element comprising:
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a nanoscale aperture within a cladding layer, the aperture forming a fluid receiving nanoscale well for receiving a fluid including fluorescent species; above the aperture layer a fluidic layer in fluidic contact with the nanoscale well; below the aperture layer a waveguide layer that provides illumination to the nanoscale well; below the waveguide layer a transmission layer that transmits light emitted from the fluorescent species in the nanoscale well; and below the transmission layer a detector layer which receives and detects the emitted light transmitted through the transmission layer, wherein the emitted light is transmitted to the detector through a solid region. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18-25. -25. (canceled)
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26. A device for measuring analytical reactions comprising:
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a. a reactor component comprising an array of optode elements, each optode element comprising; a nanoscale aperture within a cladding layer, the aperture forming a fluid receiving nanoscale well for receiving a fluid including fluorescent species; above the aperture layer a fluidic layer in fluidic contact with the nanoscale well, the fluidic layer comprising an array of fluidic conduits, each fluidic conduit extending across a plurality of optode elements; below the aperture layer a waveguide layer that provides illumination to the nanoscale well, the waveguide layer comprising an array of channel waveguides that are illuminated from the edge of the integrated device, each channel waveguide extending across a plurality of optode elements; below the waveguide layer a transmission layer that transmits light emitted from the fluorescent species in the nanoscale well; and below the transmission layer a detector layer which receives and detects the emitted light transmitted through the transmission layer, wherein the emitted light is transmitted to the detector without being transmitted through air; b. a fluidic port component connected to an edge of the reactor component, the fluidic port component comprising a port on its top surface for the introduction of fluids, and an array of fluidic conduits fluidically connected to the fluidic port and extending to the edge of the fluidic port component and connected to the fluidic conduits of the reactor component; and c. an illumination component connected to an edge of the reactor component having an optical port on its top surface for the introduction of illumination light, and an array of waveguides connected to the optical port and extending to the edge of the reactor component and connected to the waveguides of the reactor component. - View Dependent Claims (27)
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28-32. -32. (canceled)
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33. An socket assembly comprising:
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a top member comprising inputs for illumination light and fluid; a housing for receiving an integrated analysis chip, the chip comprising; an aperture layer comprising a plurality of nanoscale apertures through a cladding layer in fluidic contact with the top of the chip; a waveguide layer comprising a plurality of waveguides configured to provide illumination light to the nanoscale apertures from below, the waveguide layer having one or more illumination ports on the top surface for providing illumination light to the waveguides; a transmission layer comprising a transparent material for transmitting emitted light from the nanoscale apertures; and a detector array layer below the transmission layer having detectors electrically connected to pins extending out the bottom of the chip; and a bottom member comprising electrical contacts corresponding to the pins on the bottom of the chip; wherein the assembly is configured such that, upon receiving the chip in the housing, the aperture layer of the chip are aligned with the top member and the pins are aligned with the electrical contacts of the bottom member.
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34-35. -35. (canceled)
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36. An analytical device, comprising:
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a plurality of reaction cells, each for receiving a reactant; a plurality of sensor elements, each sensor element disposed in optical communication with at least one of the plurality of reaction cells; and a plurality of optical components, each optical component positioned to communicate an optical signal from at least one of the plurality of reaction cells to at least one of the plurality of sensor elements, wherein the plurality of reaction cells, plurality of optical components, and plurality of sensor elements are integrated into a unified analytical device. - View Dependent Claims (37, 38, 42, 43, 44)
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39-41. -41. (canceled)
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45-49. -49. (canceled)
Specification