BIODEGRADABLE STENTS AND METHODS FOR TREATING PERIODONTAL DISEASE

• US 20120021370A1
• Filed: 07/20/2010
• Published: 01/26/2012
• Est. Priority Date: 07/20/2010
• Status: Active Grant

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: Drapeau, Susan J., Shimko, Daniel Andrew, Emerton, Kelly Brook
• Granted Patent: US 9,526,600 B2
• Time in Patent Office: Days
• US Class Current: 433/25
• CPC Class Codes: A61C 19/06 Implements for therapeutic treatment radiation therapy A61N5/00
• CPC Class Codes: A61C 8/0006 Periodontal tissue or bone regeneration support means for endoprosthetic bone substitute or bone graft implants A61F2/2846
• CPC Class Codes: A61K 6/58 specially adapted for dental implants
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

Biodegradable stents and methods for selectively guided tissue regeneration in treating a periodontal defect adjacent to a root of a tooth are provided. The biodegradable stents and methods comprise a coronal portion and a transverse portion or shelf, which reduce unwanted migration of gingival epithelium, gingival connective tissue, and soft tissue and enable the cementum and periodontal ligament cells to re-establish the periodontal ligament in a proper sequence resulting in a new periodontal attachment.

Claims

1. A biodegradable stent for selectively guided tissue regeneration in treating a periodontal defect adjacent to a root of a tooth, the biodegradable stent comprising a coronal portion and a transverse portion, the coronal portion having a first surface configured to contact at least a portion of the root of the tooth and a second surface configured to contact at least a portion of the periodontal defect, the transverse portion above the coronal portion and substantially perpendicular to it, the transverse portion having a first surface configured to contact a portion of the tooth and a second surface configured to extend away from the tooth and over a portion of the periodontal defect to maintain a space between gingival epithelium tissue and periodontal ligament tissue, wherein the biodegradable stent reduces ingrowth of gingival epithelium cells and permits ingrowth of periodontal ligament cells.

2. A biodegradable stent according to claim 1, wherein the coronal portion is longer than the transverse portion and the transverse portion comprises a shelf.

3. A biodegradable stent according to claim 1, wherein the coronal portion and/or transverse portion are porous to periodontal ligament cells and cementoblasts and non-porous to gingival epithelium cells.

4. A biodegradable stent according to claim 1, wherein the biodegradable stent is affixed lateral and mesial to the tooth to prevent ingrowth of gingival epithelium cells or the biodegradable stent is one piece.

5. A biodegradable stent according to claim 1, wherein the first surface of the coronal portion and/or the first surface of the transverse portion comprise an adhesive to affix the first surface to the tooth or tooth root.

6. A biodegradable stent according to claim 1, wherein the biodegradable material comprises collagen, a hydrogel, a synthetic polymer, or a combination thereof.

7. A biodegradable stent according to claim 6, wherein the polymer comprises one or more of collagen, poly(lactide-co-glycolide) (PLGA), polylactide (PLA), polyglycolide (PGA), D-lactide, D,L-lactide, L-lactide, D,L-lactide-co-ε

-caprolactone, D,L-lactide-co-glycolide-co-ε

-caprolactone or a combination thereof.

8. A biodegradable stent according to claim 1, wherein the stent comprises one or more regions containing a therapeutic agent comprising an antimicrobial agent, a growth factor, an analgesic, an anti-inflammatory agent, or a combination thereof.

9. A biodegradable stent according to claim 1, wherein the stent is attached to the tooth by a band, strip, wire, clip or a suture that is coated with an adhesive and the band, strip, wire, clip or suture can be biodegradable or non-biodegradable.

10. A biodegradable stent for selectively guided tissue regeneration in treating a periodontal defect adjacent to a root of a tooth, the biodegradable stent comprising a coronal portion and a transverse portion, the coronal portion having a first surface configured to contact at least a portion of the root of the tooth and a second surface configured to contact at least a portion of the periodontal defect, the transverse portion above the coronal portion and substantially perpendicular to it, the transverse portion having a first surface configured to contact a portion of the tooth and a second surface configured to extend away from the tooth and over a portion of the periodontal defect to maintain a space between gingival epithelium tissue and periodontal ligament tissue, a band extending over the tooth and contacting the second surface of the coronal portion and/or the transverse portion of the biodegradable stent so as to hold the biodegradable stent in place, wherein the biodegradable stent reduces ingrowth of gingival epithelium cells and permits ingrowth of periodontal ligament cells.

11. A biodegradable stent according to claim 10, wherein the band is elastic and coated with an adhesive.

12. A biodegradable stent according to claim 10, wherein the coronal portion is longer than the transverse portion and the transverse portion comprises a shelf.

13. A biodegradable stent according to claim 10, wherein the band prevents bacterial growth and/or is a removable non-biodegradable elastic band.

14. A biodegradable stent according to claim 10, wherein the biodegradable stent is affixed lateral and mesial to the tooth to prevent ingrowth of gingival epithelium cells but allows growth of the periodontal ligament both horizontally and vertically.

15. A biodegradable stent according to claim 10, wherein the first surface of the coronal portion and/or the first surface of the transverse portion comprise an adhesive to secure the first surface to the tooth or tooth root.

16. A biodegradable stent according to claim 10, wherein the stent and/or band comprises one or more regions containing a therapeutic agent comprising an antimicrobial agent, a growth factor, an analgesic, an anti-inflammatory agent, or a combination thereof.

17. A method for selectively guided tissue regeneration in treating a periodontal defect adjacent to a root of a tooth, the method comprising affixing a biodegradable stent that maintains a space between gingival epithelium tissue and periodontal ligament tissue to the tooth, the biodegradable stent comprising a coronal portion and a transverse portion, the coronal portion having a first surface configured to contact at least a portion of the root of the tooth and a second surface configured to contact at least a portion of the periodontal defect, the transverse portion above the coronal portion and substantially perpendicular to it, the transverse portion having a first surface configured to contact a portion of the tooth and a second surface configured to extend away from the tooth and over a portion of the periodontal defect, wherein the biodegradable stent reduces ingrowth of gingival epithelium cells and permits ingrowth of periodontal ligament cells.

18. A method for selectively guided tissue regeneration according to claim 17, wherein soft tissue is separated from at least a portion of the tooth root located at the periodontal defect before the biodegradable stent is affixed to the tooth.

19. A method for selectively guided tissue regeneration according to claim 17, further comprising attaching a band over the tooth so as to allow contact with the second surface of the coronal portion and/or the transverse portion of the stent to hold the stent in place.

20. A method for selectively guided tissue regeneration according to claim 19, wherein the band prevents bacterial growth and/or is a removable non-biodegradable elastic band.