DIAGNOSIS OF ACUTE STROKES
First Claim
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1. A method of analyzing signals from a patient suspected of suffering from an acute stroke, the method comprising:
- a) processing one or more signals of impedance plethysmography (IPG), photoplethysmography (PPG), or both, obtained from the patient, to obtain one or more measures of cerebral hemodynamics of the patient, the measures comprising a measure of cerebral blood volume (CBV) and a measure of one or both of cerebral blood flow (CBF) and time to peak (TTP); and
b) applying a rule matching the measure of one or both of CBF and TTP to an extent of a penumbra.
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Abstract
A method of evaluating patients suspected of suffering from an acute stroke, the method comprising:
- a) obtaining signals of impedance plethysmography (IPG), photoplethysmography (PPG) or both, in the patient;
- b) processing the one or more signals to obtain one or more measures of cerebral hemodynamics of the patient; and
- c) applying a rule to match said measures to a disease indication or choice of therapy or both, for the patient.
19 Citations
40 Claims
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1. A method of analyzing signals from a patient suspected of suffering from an acute stroke, the method comprising:
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a) processing one or more signals of impedance plethysmography (IPG), photoplethysmography (PPG), or both, obtained from the patient, to obtain one or more measures of cerebral hemodynamics of the patient, the measures comprising a measure of cerebral blood volume (CBV) and a measure of one or both of cerebral blood flow (CBF) and time to peak (TTP); and b) applying a rule matching the measure of one or both of CBF and TTP to an extent of a penumbra. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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2. (canceled)
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39. A system for evaluating an acute ischemic stroke in a patient, comprising:
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a) an electric current source; b) at least two sensors adapted to be placed on the patient'"'"'s head, each sensor comprising an IPG electrode structure adapted to pass current from the current source through the head to measure impedance, or comprising a PPG sensor powered by the current source, or both; and c) a controller which receives one or more waveforms of one or more signals from the sensors, processes the waveforms to obtain one or more measures of cerebral hemodynamics of the patient, and is programmed with software that applies a rule to match said measures to a disease indication or choice of therapy or both, for the patient; wherein the measures comprise a measure of cerebral blood volume (CBV) and a measure of one or both of cerebral blood flow (CBF) and time to peak (TTP), and applying the rule comprises matching at least the measure of CBV to a size of an ischemia, and matching at least the measure of one or both of CBF and TTP to an extent of a penumbra.
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40-56. -56. (canceled)
Specification