System for Optimizing a Patient's Insulin Dosage Regimen

• US 20120022353A1
• Filed: 10/03/2011
• Published: 01/26/2012
• Est. Priority Date: 04/04/2008
• Status: Active Grant

• Current Assignee: Hygieia, Inc.
• Original Assignee: Hygieia, Inc.
• Inventors: Bashan, Eran, Hodish, Israel
• Granted Patent: US 8,370,077 B2
• Time in Patent Office: Days
• US Class Current: 600/365
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 10/00 ICT specially adapted for the handling or processing of patient-related medical or healthcare data for medical reports G16H15/00; for therapies or health-improving plans G16H20/00; for the handling or processing of medical images G16H30/00
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

A system for optimizing a patient'"'"'s insulin dosage regimen over time, comprising at least a first memory for storing data inputs corresponding at least to one or more components in a patient'"'"'s present insulin dosage regimen, and data inputs corresponding at least to the patient'"'"'s blood-glucose-level measurements determined at a plurality of times, and a processor operatively connected to the at least first memory. The processor is programmed at least to determine from the data inputs corresponding to the patient'"'"'s blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components in the patient'"'"'s present insulin dosage regimen in order to maintain the patient'"'"'s future blood-glucose-level measurements within a predefined range.

Claims

1. A method for updating a patient'"'"'s insulin dosage regimen, the method comprising:

storing one or more components of the patient'"'"'s insulin dosage regimen;

obtaining data corresponding to the patient'"'"'s blood glucose-level measurements determined at a plurality of times;

incrementing a timer based on at least one of the passage of a predetermined amount of time and the receipt of each blood glucose-level measurement;

tagging each of the blood glucose-level measurements with an identifier reflective of when the measurement was obtained;

determining for each of the obtained blood glucose-level measurements whether the measurement reflects a hypoglycemic event or a severe hypoglycemic event;

reducing at least one of the one or more components in the patient'"'"'s insulin dosage regimen in response to a determination that the most recent blood glucose-level measurement represents a severe hypoglycemic event;

reducing at least one of the one or more components in the patient'"'"'s insulin dosage regimen in response to a determination that there have been an excessive number of hypoglycemic events over a predefined period of time; and

determining from a plurality of the data corresponding to the patient'"'"'s blood glucose-level measurements whether and by how much to vary at least one of the one or more components in the patient'"'"'s present insulin dosage regimen in order to maintain the patient'"'"'s blood glucose-level measurements within a predefined range;

wherein the timer indicates when to perform the step of determining from a plurality of the data corresponding to the patient'"'"'s blood glucose-level measurements whether and by how much to vary at least one of the one or more components in the patient'"'"'s present insulin dosage regimen and the timer is reset at the end of the predefined period of time or earlier if there have been an excessive number of hypoglycemic events and one or more components in the patient'"'"'s insulin dosage regimen has been varied.

2. The method of claim 1, further comprising enabling a user to modify the identifier associated with each blood-glucose-level measurement.

3. The method of claim 1, further comprising determining on a predefined schedule whether and by how much to vary at least one of the one or more components in the patient'"'"'s present insulin dosage regimen.

4. The method of claim 1, further comprising determining from the patient'"'"'s blood-glucose-level measurements if the patient'"'"'s blood-glucose level measurements fall within or outside of a predefined range, and to vary at least one of the one or more components in the patient'"'"'s present insulin dosage regimen only if the patient'"'"'s blood-glucose level measurements fall outside of the predefined range.

5. The method of claim 1, further comprising determining from the patient'"'"'s blood-glucose-level measurements whether the patient'"'"'s blood-glucose-level measurements represent a normal or abnormal distribution.

6. The method of claim 5, wherein the determination of whether the patient'"'"'s blood-glucose-level measurements represent a normal or abnormal distribution comprises determining whether the third moment of the distribution of the patient'"'"'s blood-glucose-level measurements fall within a predefined range.

7. The method of claim 1, wherein the one or more components in the patient'"'"'s present insulin dosage regimen comprise a long-acting insulin dosage component.

8. The method of claim 1, wherein the one or more components in the patient'"'"'s present insulin dosage regimen comprise a short-acting insulin dosage component defined by a carbohydrate ratio or a fixed meal dose, and plasma glucose correction factor.