MEDICAL DEVICE FOR MEASURING AN ANALYTE CONCENTRATION
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Accused Products
Abstract
There is provided a medical device for measuring an analyte concentration in the subcutaneous tissue of a patient, the medical device comprising a body access unit and a processing unit. The body access unit and the processing unit are functionally connected when an analyte concentration is measured. The body access unit comprises a transcutaneous dialysis member for accessing the body of a patient. A fluid reservoir is contained at least partially in the transcutaneous dialysis member, and the fluid reservoir is at least partially bounded by a porous membrane. The fluid reservoir contains an analyte sensitive liquid. The processing unit comprises an excitation means adapted to act on a displacement member of the body access unit to generate a flow of the analyte sensitive liquid in the fluid reservoir. The processing unit further comprises a displacement sensor adapted to measure a displacement behavior of the displacement means, a damping of the displacement behavior caused by at least the viscosity of the analyte sensitive liquid contained in the fluid reservoir.
32 Citations
45 Claims
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1-23. -23. (canceled)
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24. An analyte concentration measurement system comprising a body access unit (3), the body access unit comprising:
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a transcutaneous or implantable dialysis member (4) comprising an analyte porous membrane (12) disposed at least along an analyte exchange section (28) of said dialysis member, a fluid reservoir (6) extending connected to a cavity (29) of the dialysis member, the cavity bounded at least partially by the analyte porous membrane, an analyte sensitive liquid contained in the fluid reservoir and dialysis member cavity, and a displacement member (13) configured to be displaced in a predefined manner, the displacement of the displacement member inducing flow of the analyte sensitive liquid in the cavity of the dialysis member, wherein the displacement member comprises an extension (11) inserted in the cavity of the dialysis member and configured to displace analyte sensitive liquid out of the analyte exchange section (28) and wherein the analyte sensitive liquid in the fluid reservoir serves as a reference analyte concentration. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A method of operating a device comprising:
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a body access unit (3), the body access unit comprising; a transcutaneous or implantable dialysis member (4) comprising an analyte porous membrane (12) disposed at least along an analyte exchange section (28) of said dialysis member, a fluid reservoir (6) extending connected to a cavity (29) of the dialysis member, the cavity bounded at least partially by the analyte porous membrane, an analyte sensitive liquid contained in the fluid reservoir and dialysis member cavity, and a displacement member (13) configured to be displaced in a predefined manner, the displacement of the displacement member inducing flow of the analyte sensitive liquid in the cavity of the dialysis member, wherein the displacement member comprises an extension (11) inserted in the cavity of the dialysis member and configured to displace analyte sensitive liquid out of the analyte exchange section (28) and wherein the analyte sensitive liquid in the fluid reservoir serves as a reference analyte concentration; and an extracorporeal processing unit (2) comprising; an excitation means (14) configured to drive the displacement member in movement to generate a flow of the analyte sensitive liquid contained in the dialysis member (4), means to measure the displacement behavior of the displacement member; and a signal processing unit configured to process the displacement behavior signal of the displacement member into a value representative of analyte concentration in the analyte sensitive liquid in the dialysis member, said method comprising; actuating the excitation means to move the displacement member, thereby expelling analyte sensitive liquid out of the cavity of the analyte exchange section of the dialysis member with the displacement member extension; measuring the viscosity of the analyte sensitive liquid based on the displacement behavior of the displacement member. - View Dependent Claims (41)
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42. A method of measuring an analyte concentration comprising:
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providing a medical device comprising a body access unit comprising a transcutaneous dialysis member having an analyte exchange section with an analyte porous membrane, a fluid reservoir containing an analyte sensitive liquid, and a displacement member comprising an extension inserted in a cavity of the transcutaneous dialysis member, and a processing unit comprising an excitation means configured to displace the displacement means; displacing the displacement member by means of the excitation means, thereby expelling analyte sensitive liquid out of the cavity of the analyte exchange section of the dialysis member with the displacement member extension; measuring the displacement behavior of the displacement member and determining an analyte concentration correlated to the displacement behavior of the displacement member. - View Dependent Claims (43)
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44. A method for measuring an analyte concentration with a medical device comprising a body access unit comprising a transcutaneous dialysis member having an analyte exchange section with an analyte porous membrane, a fluid reservoir containing an analyte sensitive liquid, and a displacement member comprising an extension inserted in a cavity of the transcutaneous dialysis member, the method comprising:
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measuring a displacement behavior of the displacement member within the analyte sensitive liquid, which is a measure for the viscosity of said sensitive liquid in the gap between an inner diameter of the tubular dialysis member and the longitudinal extension of the displacement member, said displacement measurements being carried out within an analyte infused sensitive liquid after dialysis and in sensitive fluid of known analyte concentration freshly streamed in from the fluid reservoir into the dialysis member for reference measurement, calculating a relative viscosity or fluidity value from the displacement measurements of the analyte infused and reference sensitive liquid, which is a function of the analyte concentration to compensate for influences by temperature or aging of the sensitive fluid, and calculating the analyte concentration from the relative viscosity or fluidity value. - View Dependent Claims (45)
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Specification