METHODS FOR TREATING DIABETES
First Claim
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1. A method of treating diabetes in an individual comprising administering to said individual a therapeutically effective amount of isolated multipotent stromal cells.
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Abstract
Transplantation of multipotent stromal cells (MSCs) into diabetic mice lowers blood sugar, increases blood insulin levels, increases the number and size of islets, and improves renal pathology. Accordingly, the invention provides methods for treating or preventing diabetes by administering isolated MSCs. The invention also provides methods for treating or preventing complications which arise from diabetes, including diabetic nephropathy, by transplanting isolated MSCs.
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Citations
57 Claims
- 1. A method of treating diabetes in an individual comprising administering to said individual a therapeutically effective amount of isolated multipotent stromal cells.
- 21. A method for preventing or inhibiting the progression of a diabetic complication in an individual in need thereof, comprising administering to said individual a therapeutically effective amount of isolated multipotent stromal cells.
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32. A method for reversing hyperglycemia in an individual in need thereof,
comprising administering to said individual a therapeutically effective amount of isolated multipotent stromal cells.
- 39. A method of reversing hypoinsulinemia in an individual in need thereof, comprising administering to said individual a therapeutically effective amount of isolated multipotent stromal cells.
- 47. A method of enhancing the regeneration or repair of pancreatic islets in an individual in need thereof, comprising administering to the individual a therapeutically-effective amount of isolated multipotent stromal cells.
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56. The use of isolated multipotent stromal cells for treating diabetes in an individual in need thereof.
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57. The use of isolated multipotent stromal cells in the manufacture of a medicament for treating diabetes in an individual in need thereof.
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