METHODS OF ENHANCING T CELL RESPONSIVENESS
First Claim
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1. A method of enhancing T cell responsiveness in a mammal, the method comprising:
- (a) identifying a mammal with, or at risk of developing, cancer, wherein the cells of the cancer are identified as expressing B7-H1 molecules on their surfaces; and
(b) administering to the subject a compound comprising an agent that interferes with an interaction between B7-H1 and a T cell.
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Abstract
The invention features methods of enhancing the responsiveness of a T cell. Such methods involve interfering with the interaction between a T cell and a B7-H1 molecule.
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17 Claims
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1. A method of enhancing T cell responsiveness in a mammal, the method comprising:
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(a) identifying a mammal with, or at risk of developing, cancer, wherein the cells of the cancer are identified as expressing B7-H1 molecules on their surfaces; and (b) administering to the subject a compound comprising an agent that interferes with an interaction between B7-H1 and a T cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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- 10. A method of enhancing the responsiveness of a T cell, the method comprising culturing, together, a T cell, a cancer cell identified as expressing B7-H1, and a compound comprising an agent that interferes with an interaction between B7-H1 and a T cell.
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