Kinase Knockdown Via Electrophilically Enhanced Inhibitors
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Abstract
Provided herein are electrophilically enhanced kinase inhibitors. Also provided herein are methods of making and utilizing the same.
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Citations
20 Claims
- 1. A compound of Formula I:
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2. (canceled)
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3. (canceled)
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13. A pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I:
- 14. A method of treating a disorder mediated by a cysteine containing kinase comprising administering to an individual in need thereof a therapeutically effective amount of a compound of Formula I:
- 18. A method of binding a cysteine containing kinase to a compound of Formula I comprising contacting the kinase with the compound of Formula I, wherein the compound of Formula I has the structure:
Specification