Passive Microwave Assessment of Human Body Core to Surface Temperature Gradients and Basal Metabolic Rate

• US 20120029369A1
• Filed: 09/04/2011
• Published: 02/02/2012
• Est. Priority Date: 10/31/2007
• Status: Abandoned Application

• Current Assignee: Carl Lyster, David Icove, Michael Zemel, Neil Feld
• Original Assignee: Carl Lyster, David Icove, Michael Zemel, Neil Feld
• Inventors: Icove, David J., Zemel, Michael B., Lyster, Carl T., Feld, Neil
• Application Number:
  US13/225,452
• Publication Number:
  US 20120029369A1
• Time in Patent Office: Days
• US Class Current: 600/504
• CPC Class Codes: G01K 11/006 using measurement of the effect of a material on microwaves or longer electromagnetic waves, e.g. measuring temperature via microwaves emitted by the object G01K17/003, G01J5/00 take precedence; measuring the effect of a material on X-, gamma- or particle radiation G01K11/30
• CPC Class Codes: G01K 13/20 Clinical contact thermometers for use with humans or animals
• CPC Class Codes: G01K 3/14 in respect of space

Abstract

A passive microwave thermography apparatus uses passive microwave antennas designed for operation, for example, at WARC protected frequencies of 1.400 to 1.427 GHz and 2.690 to 2.70 GHz (for core body gradient temperature measurement) and 10.68 to 10.700 GHz or higher microwave frequency (for surface body gradient temperature measurement) and a related directional antenna or antenna array to measure microwave radiation emanating from an animal, especially, a human body. The antennae may be radially directed toward a point within or on the surface of a human body for comparison with known temperature distribution data for that point and a given ambient temperature. Each frequency band may provide a plurality of adjacent noise measuring channels for measuring microwave noise naturally emitted by the human body. The apparatus measures short-term changes in, for example, core and body surface temperatures to establish a basal metabolic rate. Changes in core body temperature may be stimulated by the administration of food or certain organic and drug-related substances or stress to induce a change in basal metabolic rate over time. These changes correlate directly with a human subject'"'"'s metabolism rate at rest and under certain dietary constraints and can be used to determine courses of treatment for obesity, metabolic disease, and other disorders. The apparatus can also be used to remotely monitor patients and subjects without physical contact.

Claims

1. A system for the assessment of human blood flow gradients at a radial depth of a human subject comprising

a passive microwave receiver for operation within a selected microwave frequency range whereby the lower the frequency range, the greater the depth of penetration of a human body, each selected frequency range comprising at least one noise measuring channel, the passive microwave receiver comprising a directional antenna for radial direction toward a specific location on the skin surface of the human subject where the location is proximate to a human vascular system comprising one of an artery or vein of one of an ear, the hypothalamus, the nasopharyngeal cavity, a rectum, a breast, a heart, an arm, a hand, a leg, a foot and a tongue.

2. A system as recited in claim 1 wherein the selected microwave frequency range is a selected WARC protected frequency range comprising 1.400 to 1.427 GHz, providing a 27 MHz bandwidth.

3. A system as recited in claim 2 wherein the 27 MHz bandwidth is further divided into a plurality of adjacent noise-measuring channels.

4. A system as recited in claim 3 wherein the quantity of the plurality of adjacent noise-measuring channels is selected such that the inter-spatial difference between center frequencies of noise-measuring channels corresponds to the inter-spatial difference between blood vessels of the subject each at a predetermined radial depth.

5. A system as recited in claim 1 further comprising a computer and memory, the memory for storing three dimensional coordinates of a human body and corresponding expected temperatures for the coordinates of human tissue for comparison with measurements of the at least one noise measuring channel.

6. A system as recited in claim 1 further comprising a computer and memory, the memory for storing three dimensional coordinates of a human body and corresponding expected temperatures for the coordinates of blood vessels for comparison with measurements of the at least one noise measuring channel.

7. A system as recited in claim 1, wherein the selected microwave frequency range is a selected WARC protected frequency range comprising 2.690 to 2.700 GHz, providing a 10 MHz bandwidth.

8. A system as recited in claim 7 wherein the 10 MHz bandwidth is further divided into a plurality of noise-measuring channels.

9. A system as recited in claim 8 wherein the quantity of the plurality of noise-measuring channels is selected such that the inter-spatial difference between center frequencies of noise-measuring channels corresponds to the inter-spatial difference between blood vessels of the subject at a predetermined radial depth.

10. A system as recited in claim 1, wherein the selected microwave frequency range is a selected WARC protected frequency range comprising 10.680 to 10.700 GHz, providing a 20 MHz bandwidth.

11. A system as recited in claim 10 wherein the 20 MHz bandwidth is further divided into a plurality of noise-measuring channels.

12. A system as recited in claim 11 wherein the quantity of the plurality of noise-measuring channels is selected such that the inter-spatial difference between center frequencies of noise-measuring channels corresponds to the inter-spatial difference between blood vessels of the subject at a predetermined radial depth.

13. A system as recited in claim 1 wherein the selected microwave frequency range is a selected WARC protected frequency range comprising at least two of 1.400 to 1.427 GHz, 1.6 to 1.7 GHz, 2.69 to 2.70 GHz, 10.680 to 10.700 GHz and 23.600 to 24.000 GHz.

14. A system as recited in claim 1 comprising a scale and an antenna system for each of left and right legs or feet of the subject, the scale for wireless connection to a signal processor, the scale comprising first and second directional antennae for radial direction toward the left and right legs or feet of the subject respectively.

15. An assessment method for assessing human metabolic response including blood flow over time in response to a pressure occlusion comprising

directing a passive microwave receiver having a plurality of adjacent noise-measuring channels within a predetermined microwave frequency range, the passive microwave receiver having a directional antenna for radial direction at a given body part of a human under observation comprising one of a foot or leg,

determining from the predetermined microwave frequency range for receiving a noise-measuring channel and from said radial direction, a corresponding radial depth of human body tissue configured to reach a vascular system of an artery and vein of the foot or leg,

comparing a location of measurement and radial depth of the vascular system with stored data for blood flow over time of a normal human body through the vascular system and

determining a blood flow in the vascular system over time for the plurality of adjacent noise-measuring channels and corresponding radial depths.

16. An assessment method as recited in claim 15 further comprising

introducing a stimulus to the human under observation restricting blood flow in the leg or foot,

determining a blood flow change over time for the plurality of noise-measuring channels and corresponding radial depths.

17. An assessment method as recited in claim 16 wherein the stimulus comprises a blood pressure occlusion provoking a transient increase in one of an artery or vein of the vascular system.

18. An assessment method as recited in claim 16 wherein the stimulus comprises controlled exercise.

19. An assessment method as recited in claim 16 wherein the ambient environmental temperature is maintained at a constant.

20. An assessment method according to claim 17 comprising applying a blood pressure cuff at different pressures proximate to measurement sites of blood flow, a low pressure permitting arterial flow and impairing venous return, a high pressure impairing both arterial flow and venous return.