POLYMERIC DRUG DELIVERY SYSTEMS AND PROCESSES FOR PRODUCING SUCH SYSTEMS
First Claim
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1. A subcutaneous delivery system comprising:
- i) a biocompatible thermoplastic elastomer matrix,ii) a therapeutic agent dispersed homogeneously in said matrix, andiii) a biocompatible therapeutic agent impermeable thermoplastic polymer coating said matrix,wherein said delivery system has a geometry such that there is an external coated wall and an internal uncoated wall forming an opening for release of said therapeutic agent, and the distance between the uncoated wall and the coated wall opposite the uncoated wall is substantially constant throughout the delivery system.
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Abstract
The subject invention relates to implants for delivery of therapeutic agents such as opioids, and the manufacture and uses of such implants.
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Citations
52 Claims
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1. A subcutaneous delivery system comprising:
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i) a biocompatible thermoplastic elastomer matrix, ii) a therapeutic agent dispersed homogeneously in said matrix, and iii) a biocompatible therapeutic agent impermeable thermoplastic polymer coating said matrix, wherein said delivery system has a geometry such that there is an external coated wall and an internal uncoated wall forming an opening for release of said therapeutic agent, and the distance between the uncoated wall and the coated wall opposite the uncoated wall is substantially constant throughout the delivery system. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 27)
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25. A subcutaneous delivery system comprising
i) a thermoplastic elastomer matrix, ii) a therapeutic agent embedded homogeneously in said matrix, iii) a biocompatible therapeutic agent impermeable coating said matrix wherein said delivery system has a geometry such that there is an external coated wall and an internal uncoated wall forming an opening for release of said therapeutic agent, and the distance between the uncoated wall and the coated wall opposite the uncoated wall is substantially constant throughout the delivery system.
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26. A subcutaneous delivery system comprising:
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a biocompatible thermoplastic polyurethane matrix, a therapeutic agent embedded homogeneously in said matrix, and a biocompatible therapeutic agent impermeable thermoplastic polyurethane coating said matrix, wherein said delivery system has a geometry such that there is an external coated wall and an internal uncoated wall forming an opening for release of said therapeutic agent, and the distance between the uncoated wall and the coated wall opposite the uncoated wall is substantially constant throughout the delivery system.
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28. A method of producing a subcutaneous implant comprising the steps of:
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i) forming a matrix polymer sheet of a first thermoplastic polymeric resin with a therapeutic agent dispersed in said matrix, ii) die cutting said sheet to form polymer matrix, and iii) coating said polymer matrix with a second thermoplastic polymeric resin which is impermeable to said therapeutic agent. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 45)
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41. A method of producing a subcutaneous implant delivery system comprising the steps of:
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i) hot melt extrusion of a first thermoplastic polymeric elastomer resin with a therapeutic agent to form a polymer matrix in a cylindrical shape, ii) powder coating and thermal fusing a second thermoplastic polymeric elastomer resin on said polymer matrix to form a therapeutic agent impermeable coating, and iii) forming an uncoated channel in said implant.
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42. A method of producing a subcutaneous implant delivery system having an uncoated central channel comprising the steps of:
co-extruding of a first thermoplastic polymeric elastomer resin and a therapeutic agent and a second thermoplastic polymeric elastomer resin into a multiple cavity die to form a coated polymer matrix. - View Dependent Claims (43, 44)
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46. A method of producing a subcutaneous implant comprising the steps of:
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i) mixing a first thermoplastic elastomer polymeric resin with a polar solvent to form a polymer solution, ii) adding an therapeutic agent to the solution, iii) introducing the solution into a mold, iv) drying the solution to form a matrix, and v) coating the matrix with a second thermoplastic elastomer polymeric resin which is impermeable to the therapeutic agent. - View Dependent Claims (47, 48, 49, 50, 51, 52)
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Specification