PROTECTION OF BIOANALYTICAL SAMPLE CHAMBERS

• US 20120034687A1
• Filed: 10/14/2011
• Published: 02/09/2012
• Est. Priority Date: 04/15/2009
• Status: Active Grant

• Current Assignee: Biocartis NV (Biocartis Group NV)
• Original Assignee: Biocartis SA (Biocartis Group NV)
• Inventors: De Gier, Ronald, Versleegers, Jozef C.M.
• Granted Patent: US 9,079,182 B2
• Time in Patent Office: Days
• US Class Current: 435/287.2
• CPC Class Codes: B01L 2200/141 Preventing contamination, tampering
• CPC Class Codes: B01L 2200/18 Transport of container or devices
• CPC Class Codes: B01L 2300/041 Connecting closures to device or container
• CPC Class Codes: B01L 7/52 with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples amplification or hybridisation processes per se C12Q1/68; controlling sequential reactions for synthesis B01J19/0046
• CPC Class Codes: B01L 9/52 Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips

Abstract

An apparatus for performing bioanalytic processing and analysis, a bioanalytical reaction device, and a cartridge thereof are provided. The cartridge contains a housing and at least one sample chamber in a platform for storing biological samples, which the bioanalytical reaction device can process and analyze. The platform is movably connected to the housing such that the platform is movable between a stowed position, in which the sample chamber is protected by the housing, and an extended position, in which the sample chamber is outside of the housing. The bioanalytical reaction device includes an actuation device for moving the platform between the stowed and extended positions.

Claims

1. A cartridge for a bioanalytical reaction device, comprising:

at least one sample chamber for a sample, the at least one sample chamber having a wall through which the sample can be processed or analyzed by the bioanalytical reaction device;

a housing;

a platform having the at least one sample chamber, wherein the platform is moveably connected to the housing such that the platform is moveable between a stowed position, in which the wall is protected by the housing, and an extended position, in which the wall is outside of the housing; and

an actuation device connected to the platform to move the platform between the stowed and extended positions.

2. The cartridge of claim 1, wherein the at least one sample chamber is connected to a channel for filling the at least one sample chamber, the channel ending in the vicinity of the actuation device.

3. The cartridge of claim 2, wherein a part of the channel is located within the actuation device.

4. The cartridge of claim 1, wherein the wall is arranged at a first side of the platform, the platform having a second side opposite to the first side, and wherein the platform, when in the extended position, is accessible from the first side and the second side by the bioanalytical reaction device for processing or analyzing the sample.

5. The cartridge of claim 1, wherein at least one dimension of the cartridge with the platform in the extended position is bigger than the dimension with the platform in the stowed position.

6. The cartridge of claim 1, wherein the platform is rotatably connected to the housing.

7. The cartridge of claim 6, wherein the actuation device is a shaft and the platform is connected to the shaft for rotating the platform about a rotation axis.

8. The cartridge of claim 1, wherein the platform is slidably connected to the housing.

9. The cartridge of claim 1, wherein the platform is a plate, which, in the stowed position, is arranged between a first wall and a second wall of the housing.

10. The cartridge of claim 1, wherein the at least one sample chamber is formed by an opening in the platform, which is covered by a foil forming the wall.

11. A bioanalytical reaction device, comprising:

a cartridge having at least one sample chamber for a sample, a housing, a platform, and an actuation device, the platform having the at least one sample chamber with a wall through which the sample can be processed or analyzed, the platform being moveably connected to the housing such that the platform is moveable between a stowed position, in which the wall is protected by the housing, and an extended position, in which the wall is outside of the housing, the actuation device is connected to the platform to move the platform between the stowed and extended positions;

a slot for receiving the cartridge; and

an actuator engaging the actuation device when the cartridge is received in the slot so that the actuator extends and stows the platform.

12. The bioanalytical reaction device of claim 11, wherein the actuator is a motor.

13. The bioanalytical reaction device of claim 11, further comprising:

a reservoir for filling the at least one sample chamber, wherein the reservoir is connectable with the at least one sample chamber over a line ending in a mechanical connection of the actuator with the actuation device.

14. The bioanalytical reaction device of claim 11, further comprising a cartridge presence sensor for detecting a presence of the cartridge in the slot.

15. The bioanalytical reaction device of claim 14, wherein the actuator moves the platform to the extended position when the cartridge presence sensor detects the presence of the cartridge in the slot.

16. The bioanalytical reaction device of claim 11, wherein the platform is rotatably connected to the housing.

17. The bioanalytical reaction device of claim 11, wherein the actuation device is a shaft and the platform is connected to the shaft for rotating the platform about a rotation axis.

18. The bioanalytical reaction device of claim 11, wherein the platform is slidably connected to the housing.

19. The bioanalytical reaction device of claim 11, wherein the platform is a plate, which, in the stowed position, is arranged between a first wall and a second wall of the housing.

20. The bioanalytical reaction device of claim 11, wherein the at least one sample chamber is formed by an opening in the platform, which is covered by a foil forming the wall.