PHENOXAZINE DERIVATIVES AND METHODS OF USE THEREOF

• US 20120035359A1
• Filed: 08/01/2011
• Published: 02/09/2012
• Est. Priority Date: 07/30/2010
• Status: Active Grant

• Current Assignee: Washington University In St Louis
• Original Assignee: Washington University In St Louis
• Inventors: Zipfel, Gregory, Han, Byung, Mach, Robert, Chu, Wenhau
• Granted Patent: US 8,735,575 B2
• Time in Patent Office: Days
• US Class Current: 544/102
• CPC Class Codes: C07D 265/38 [b, e]-condensed with two six-membered rings
• CPC Class Codes: C07D 413/12 linked by a chain containing hetero atoms as chain links

Abstract

The present invention encompasses phenoxazine derivatives and methods of use thereof.

Claims

1. A compound of formula (II):

2. The compound of claim 1, wherein R⁴ is (CH₂)_x.

3. The compound of claim 1, wherein R⁴ is ((CH₂)_yO)_z.

4. The compound of claim 1, wherein R⁴ is ((CH₂)_aO(CH₂)_b).

5. The compound of claim 1, wherein R⁵ is a cyclic ring.

6. The compound of claim 1, wherein R⁵ is a heterocyclic ring.

7. A compound of formula (III):

8. The compound of claim 7, wherein R⁷ is ((CH₂)_cO)_d.

9. The compound of claim 8, wherein R⁸ is hydrogen.

10. The compound of claim 8, wherein R⁸ is a hydrocarbyl.

11. The compound of claim 8, wherein R⁸ is a substituted hydrocarbyl.

12. The compound of claim 7, wherein R⁷ is ((CH₂)_eO(CH₂)_f).

13. The compound of claim 8, wherein R⁸ is hydrogen.

14. The compound of claim 8, wherein R⁸ is a hydrocarbyl.

15. The compound of claim 8, wherein R⁸ is a substituted hydrocarbyl.

16. A compound of formula (IV):

17. The compound of claim 16, wherein R¹⁰ is a halogen.

18. The compound of claim 16, wherein R¹⁰ is an alkenyl group.

19. The compound of claim 16, wherein R¹⁰ is an alkynyl group.

20. The compound of claim 16, wherein R¹⁰ is a substituted hydrocarbyl.