PORTABLE RAMAN DIAGNOSTIC SYSTEM
First Claim
1. A method for measuring glucose concentration comprising:
- illuminating a region of tissue having a glucose concentration to be measured with light having a plurality of wavelengths;
detecting a plurality of Raman spectral regions with light from the tissue in response to the illuminating wavelengths of light; and
analyzing the spectral data to determine a concentration of an analyte in the region of tissue.
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Accused Products
Abstract
The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.
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Citations
24 Claims
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1. A method for measuring glucose concentration comprising:
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illuminating a region of tissue having a glucose concentration to be measured with light having a plurality of wavelengths; detecting a plurality of Raman spectral regions with light from the tissue in response to the illuminating wavelengths of light; and analyzing the spectral data to determine a concentration of an analyte in the region of tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A device for measuring glucose concentration within a body comprising:
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a light source system for illuminating a region of tissue with a plurality of wavelengths; an optical system to deliver and collect light from the region of tissue in response to the illuminating light; and a detector that detects a plurality of spectral regions of Raman shifted light collected by the optical system. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification