BLOOD COAGULATION SYSTEM ANALYZER, AND BLOOD COAGULATION SYSTEM ANALYSIS METHOD AND PROGRAM

• US 20120035450A1
• Filed: 01/07/2010
• Published: 02/09/2012
• Est. Priority Date: 01/08/2009
• Status: Active Grant

• Current Assignee: Sony Corporation (Sony Group Corp.)
• Original Assignee: Song Corporation
• Inventors: Hayashi, Yoshihito
• Granted Patent: US 9,518,997 B2
• Time in Patent Office: Days
• US Class Current: 600/369
• CPC Class Codes: G01N 27/026 Dielectric impedance spectroscopy electrochemical impedance spectroscopy for measuring corrosion G01N17/02
• CPC Class Codes: G01N 33/4905 Determining clotting time of blood by chemical methods G01N33/86, C12Q1/54
• CPC Class Codes: G01N 33/86 involving blood coagulating time or factors, or their receptors

Abstract

A blood coagulation system analysis device capable of analyzing a blood coagulation system with high accuracy, and a method and a program for analysis of a blood coagulation system are proposed.

The blood coagulation system is observed as a temporal change in permittivity before the viscoelasticity manifestation timing (timing at which blood starts to clot from the viewpoint of viscoelasticity (in greater detail, timing at which active polymerization of fibrin monomers starts)). A permittivity of blood which is positioned between a pair of electrodes is measured at predetermined time intervals after the anticoagulant effect acting on the blood is ended, and from the measurement result, a degree of the action of the blood coagulation system is analyzed.

Claims

1. A blood coagulation system analysis device comprising:

a pair of electrodes;

application means for applying an alternating voltage to the pair of electrodes at predetermined time intervals;

measurement means for measuring a permittivity of blood which is positioned between the pair of electrodes; and

analysis means for analyzing a degree of the action of a blood coagulation system by using a permittivity of blood which is measured at the time intervals after the anticoagulant effect acting on the blood is ended.

2. The blood coagulation system analysis device according to claim 1,

wherein the analysis means estimates a timing at which certain viscoelastic characteristics are exhibited from a parameter showing an amount of increase in permittivity of a frequency to be considered within a predetermined time period after the anticoagulant effect acting on the blood is ended.

3. The blood coagulation system analysis device according to claim 1,

wherein the analysis means evaluates a risk of thrombus from a parameter showing an amount of increase in permittivity of a frequency to be considered within a predetermined time period after the anticoagulant effect acting on the blood is ended.

4. The blood coagulation system analysis device according to claim 2,

wherein the pair of electrodes is opposed to each other with the position at which blood is to be positioned interposed therebetween.

5. The blood coagulation system analysis device according to claim 1,

wherein the analysis means divides permittivity of a specific frequency and permittivity of a frequency different from the above frequency within a predetermined time period after the anticoagulant effect acting on the blood is ended by expressing them as a ratio between the permittivity and permittivity at a reference time to analyze, using the division result, the degree of the action of the blood coagulation system.

8. The blood coagulation system analysis device according to claim 3,

wherein the pair of electrodes is opposed to each other with the position at which blood is to be positioned interposed therebetween.

6. A blood coagulation system analysis method comprising:

an application step of applying an alternating voltage to a pair of electrodes at predetermined time intervals;

a measurement step of measuring permittivity of blood which is positioned between the pair of electrodes; and

an analysis step of analyzing a degree of the action of a blood coagulation system by using a permittivity of blood which is measured at the time intervals after the anticoagulant effect acting on the blood is ended.

7. A program to cause:

an application portion which applies an alternating voltage to apply an alternating voltage to a pair of electrodes at predetermined time intervals;

a measurement portion which measures permittivity to measure permittivity of blood which is positioned between the pair of electrodes; and

an analysis portion which analyzes a blood coagulation system to analyze a degree of the action of a blood coagulation system by using a permittivity of blood which is measured at the time intervals after the anticoagulant effect acting on the blood is ended.