Multiplexed, Multi-Electrode Neurostimulation Devices with Integrated Circuits Having Integrated Electrodes

• US 20120035684A1
• Filed: 02/09/2010
• Published: 02/09/2012
• Est. Priority Date: 02/09/2009
• Status: Abandoned Application

• Current Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Inventors: Thompson, Todd, Zdeblick, Mark, Strand, Angela, Jensen, Marc
• Application Number:
  US13/146,896
• Publication Number:
  US 20120035684A1
• Time in Patent Office: Days
• US Class Current: 607/59
• CPC Class Codes: A61N 1/025 Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated control circuit operatively coupled to one or more electrodes. Also provided are methods of manufacturing wherein the application of laser welding is avoided in forming the satellite electrode structures and an integrated control circuit thereof is thereby shielded from mechanical stress during satellite manufacture. Additionally provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.

Claims

1. An implantable device for target site stimulation, the device comprising:

an integrated control circuit having a controller circuit, a selectable pathway, and a first surface, the controller circuit to alternately enable and disable the selectable pathway, and the selectable pathway to provide electrical power to the surface as directed by the controller circuit; and

an electrode, the electrode coupled to the first surface and to deliver the electrical power received from the selectable pathway to the target site.

2. The implantable device of claim 1, wherein the electrode is convex in shape and extends away from the first surface.

3. The implantable device of claim 1, wherein the electrode covers at least a portion of the first surface.

5. The implantable device of claim 1, further comprising a second electrode coupled to the first surface and to deliver the electrical power received from the selectable pathway to the target site.

6. The implantable device of claim 1, further comprising a sensor to acquire biomedical data.

7. The implantable device of claim 1, further comprising

at least one support structure;

and

at least one electrode extending from an inside surface of the support structure.

8. The implantable device of claim 1, further comprising a plurality of additional electrodes coupled to the first surface.

9. The implantable device of claim 1, further comprising:

a second surface of the integrated control circuit coupled to selectable pathway; and

a second electrode coupled to the second surface, the second electrode to deliver electrical power to the target site received from the selectable current pathway.

10. The implantable device of claim 9, wherein the second surface is positioned substantively orthogonally to the first surface.

11. The implantable device of claim 9, wherein the second surface is positioned substantively parallel to the first surface.

12. The implantable device of claim 1, wherein the integrated control circuit is hermetically sealed.

13. The implantable device of claim 1, further comprising a metal layer disposed between the first surface and the electrode.

14. The implantable device of claim 13, wherein the metal layer selectively covers the first surface.

15. The implantable device of claim 1, the integrated control circuit further comprising:

a power bus to transfer electrical power from a common conductor to the selectable pathway; and

a device communications bus to receive commands from addressed to the implantable device from a lead communications bus.

16. The device of claim 15, further comprising a metal layer disposed between the first surface and the electrode.

17. The device of claim 16, further comprising an insulative layer disposed between the metal layer and the target site.

18. The implantable device of claim 16, wherein the metal layer selectively covers the first surface.

19. The implantable device of claim 16, wherein the metal layer substantively encloses the integrated control circuit and wherein the device further comprises a first aperture to accept a power bus to deliver electrical power to the integrated control circuit and a second aperture to accept the device communications bus to deliver commands and data to the integrated control circuit.

4. (canceled)

20. An implantable lead for target site stimulation, the lead comprising:

a common conductor;

a lead communications bus;

a plurality of satellite structures, each satellite structure including;

an integrated control circuit having a controller circuit, a selectable pathway, and a first surface;

the controller circuit coupled with the lead communications bus and with the selectable pathway, and the controller circuit to alternately enable and disable the selectable pathway as directed by commands addressed through and received from the lead communications bus;

the selectable pathway coupled with the common conductor and the selectable pathway to provide electrical power received from the common conductor to the surface as directed by the controller circuit; and

an electrode, the electrode coupled to the first surface and to deliver the electrical power received from the selectable pathway to the target site.

21. A system comprising:

an implantable controller, the implantable controller to provide electrical stimulation pulses;

a common conductor coupled with the implantable controller to receive electrical stimulation pulses; and

a multiplexed, multi-electrode component to provide at least one of neural stimulation and neural sensing, the multiplexed, multi-electrode component comprising two or more individually addressable satellite electrode structures electrically coupled to the common conductor to receive electrical stimulation pulses, wherein each satellite structure comprises an integrated circuit forming at least one electrode, the multiplexed, multi-electrode component operatively coupled to the implantable controller.

22. A method of manufacture comprising the steps of:

providing a substrate;

creating an integrated control circuit upon the substrate to receive electrical stimulation commands and electrical stimulation energy and

creating at least one electrode upon a first surface of the integrated circuit to transfer the electrical stimulation energy to a target site.

23. The method of claim 22, wherein creating the electrode comprises providing a metal layer associated with the first surface.

24. The method of claim 23, further comprising:

creating an insulative layer over the metal layer; and

partially removing the insulative layer to expose a partial top surface area of the metal layer.

25. The method of claim 24, wherein the partial removal of the insulative layer from the metal layer is accomplished by at least one of laser ablation technique or laser electroformimg technique.

28. The method of claim 23, wherein the step of providing the metal layer comprises cathodic arc deposition.

29. The method of claim 23, wherein the step of creating the electrode comprises exposing a top surface of the electrode.

26-27. -27. (canceled)