Systems, devices, and methods including implantable devices with anti-microbial properties

• US 20120041285A1
• Filed: 02/14/2011
• Published: 02/16/2012
• Est. Priority Date: 12/04/2008
• Status: Abandoned Application

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Goodall, Eleanor V., Hyde, Roderick A., Sweeney, Elizabeth A., Wood, Lowell L. Jr.
• Application Number:
  US12/931,929
• Publication Number:
  US 20120041285A1
• Time in Patent Office: Days
• US Class Current: 600/309
• CPC Class Codes: A61L 17/145 Coating
• CPC Class Codes: A61L 2/0011 using physical methods
• CPC Class Codes: A61L 2/08 Radiation
• CPC Class Codes: A61L 2/14 Plasma, i.e. ionised gases
• CPC Class Codes: A61L 2/232 layered or coated
• CPC Class Codes: A61L 2/24 Apparatus using programmed or automatic operation
• CPC Class Codes: A61L 2/26 Accessories or devices or components used for biocidal treatment
• CPC Class Codes: A61L 2202/14 Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
• CPC Class Codes: A61L 2300/10 containing or releasing inorganic materials
• CPC Class Codes: A61L 2300/108 Elemental carbon, e.g. charcoal
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/00 Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters shape or structure of catheters A61M25/00
• CPC Class Codes: A61L 29/08 Materials for coatings
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/024 Carbon; Graphite
• CPC Class Codes: A61L 31/026 Ceramic or ceramic-like structures, e.g. glasses
• CPC Class Codes: A61L 31/08 : Materials for coatings
• CPC Class Codes: A61L 31/14 : Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/16 : Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 25/0045 : multi-layered, e.g. coated coating materials A61L29/08
• CPC Class Codes: A61M 27/006 : Cerebrospinal drainage; Accessories therefor, e.g. valves
• CPC Class Codes: B82Y 30/00 : Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: B82Y 40/00 : Manufacture or treatment of nanostructures
• CPC Class Codes: B82Y 5/00 : Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Systems, devices, methods, and compositions are described for providing an actively controllable implant configured to, for example, monitor, treat, or prevent microbial growth or adherence to the implant.

Claims

1. A insertable device, comprising:

a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways;

one or more anti-microbial regions including at least one D-amino acid coating on at least one of the outer surface, inner surface, or embedded in the body structure.

3. The insertable device of claim 1, wherein at least one of the anti-microbial regions is actuatable.

16. The insertable device of claim 1, further comprising at least one light source.

49. The insertable device of claim 1, wherein at least one of the anti-microbial regions includes at least one electroactive polymer.

53. The insertable device of claim 1, wherein the body structure further includes at least one porous material.

54. The insertable device of claim 1, wherein at least one of the plurality of anti-microbial regions includes at least one porous material.

55. The insertable device of claim 54, wherein the at least one porous material is configured to capture at least one microorganism proximate to at least one of the inner surface or the outer surface of the body structure.

61. The insertable device of claim 1, further comprising at least one sensor.

62. The insertable device of claim 61, wherein the at least one sensor is configured to detect a microbial component proximate the body structure.

74. The insertable device of claim 1, further comprising a power source.

77. The insertable device of claim 74, wherein the power source comprises at least one rechargeable power source.

80. The insertable device of claim 1, further comprising at least one of a battery, capacitor, or a mechanical energy store.

81. The insertable device of claim 1, further comprising a power receiver configured to receive power from an ex vivo power source.

82. The insertable device of claim 1, further comprising a power receiver configured to receive power from an in vivo power source.

84. The insertable device of claim 1, further comprising at least one active agent reservoir configured to release at least one active agent to at least one of the outer surface or inner surface of the body structure.

86. The insertable device of claim 84, further comprising a release system.

87. The insertable device of claim 84, further comprising control circuitry configured for selectively opening at least a portion of the at least one active agent reservoir.

92. The insertable device of claim 1, further comprising a processor to control activation of at least one anti-microbial region.

93. The insertable device of claim 92, wherein the processor is configured to be responsive to the at least one sensor.

2. (canceled)

4-15. -15. (canceled)

17-48. -48. (canceled)

50-52. -52. (canceled)

56-60. -60. (canceled)

63-73. -73. (canceled)

75-76. -76. (canceled)

78-79. -79. (canceled)

83. (canceled)

85. (canceled)

88-91. -91. (canceled)

94. A insertable device, comprising:

a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways;

one or more selectively actuatable anti-microbial regions including at least one anti-microbial reservoir including at least one D-amino acid, and directed to deliver at least one D-amino acid to at least one of the outer surface, inner surface, or internal body structure.

97. The insertable device of claim 94, wherein the at least one anti-microbial coating is configured for time-release of at least one anti-microbial agent.

95-96. -96. (canceled)

98-99. -99. (canceled)