METHOD AND APPARATUS FOR MEASURING SAMPLE REACTION RESULTS ON BIOSENSOR

• US 20120043201A1
• Filed: 01/20/2011
• Published: 02/23/2012
• Est. Priority Date: 08/08/2005
• Status: Active Grant

• Current Assignee: Osang Healthcare Co., Ltd.
• Original Assignee: INFOPIA CO., LTD
• Inventors: BAE, Byeong-woo, LEE, Sung-dong, SUK, Hong-seong, YOO, Jin-a
• Granted Patent: US 8,702,923 B2
• Time in Patent Office: Days
• US Class Current: 204/403.01
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52

Abstract

Disclosed is a method of measuring sample reaction results on a biosensor having a working electrode and other electrodes, including: applying voltage between the working electrode and each of the other electrodes and detecting the amount of current flowing through the working electrode to determine whether or not a sample is injected; applying voltage between the working electrode and one of the other electrodes and re-detecting the amount of current flowing through the working electrode; and acquiring and displaying a concentration value as a sample reaction result corresponding to the amount of detected current.

Claims

1. An apparatus for measuring sample reaction results on a biosensor having a working electrode, a checking electrode and a counter electrode, the apparatus comprising a microcontroller configured:

to apply voltage between the checking electrode and the working electrode, and between the counter electrode and the working electrode;

to detect the amounts of currents flowing through the working electrode, and a time interval between times when the amounts of two currents begin to be detected; and

to determine whether or not a sample is properly injected by comparing the amounts of detected currents and/or the detected time interval with predetermined threshold values.

2. A apparatus of claim 1, wherein the microcontroller is further, if it is determined that the sample is properly injected, configured:

to apply voltage between the working electrode and the counter electrode;

to re-detect the amount of current flowing through the working electrode; and

to acquire a concentration value as a sample reaction result corresponding to the amount of the re-detected current.

3. A apparatus of claim 1, wherein the microcontroller is configured to determine that the sample is properly injected if the detected time interval is equal to or shorter than the predetermined threshold value.

4. A apparatus of claim 1, wherein the microcontroller is further configured to display error message if the detected time interval is longer than the predetermined threshold value.

5. A apparatus of claim 1, wherein the microcontroller is further configured to display error message if at least one of the amounts of the detected currents is less than the predetermined threshold value.

6. A apparatus of claim 1, wherein the microcontroller is configured to determine that the sample is properly injected if all of the amounts of the detected currents are equal to or more than the predetermined threshold value.

7. An apparatus for measuring sample reaction results on a biosensor having a working electrode, a checking electrode and a counter electrode, the apparatus comprising a microcontroller configured:

to apply voltage between the checking electrode and the working electrode;

to detect first current between the checking electrode and the working electrode;

to apply voltage between the counter electrode and the working electrode;

to detect second current between the counter electrode and the working electrode;

to measure a time interval from a time at which the first current begins to be detected to a time at which the second current begins to be detected;

to comparing the first and second currents with a predetermined threshold current value and the time interval with a predetermined time value;

to re-apply voltage between the counter electrode and the working electrode if the first and second currents are equal to or more than the predetermined threshold current value and/or the time interval is equal to or shorter than the predetermined time value;

to measure third current between the counter electrode and the working electrode; and

to compute a concentration value corresponding to the third current as the sample reaction results.

8. A apparatus of claim 7, wherein the microcontroller is further configured to display error message if the time interval is longer than the predetermined time value.

9. A apparatus of claim 7, wherein the microcontroller is further configured to display error message if at least one of the first and second currents is less than the predetermined threshold current value.

10. An apparatus for measuring sample reaction results on a biosensor having a working electrode, a checking electrode and a counter electrode, the apparatus comprising a microcontroller configured:

to apply voltage between the checking electrode and the working electrode, and between the counter electrode and the working electrode;

to detect a time interval between times when the amounts of two currents begin to be detected; and

to determine whether or not a sample is properly injected by comparing the detected time interval with a predetermined threshold value;

if it is determined that the sample is properly injected, to apply voltage between the working electrode and the counter electrode;

to re-detect the amount of current flowing through the working electrode; and

to compute a concentration value as a sample reaction result corresponding to the amount of the re-detected current.

11. An apparatus for measuring sample reaction results on a biosensor having a working electrode, a checking electrode and a counter electrode, the apparatus comprising a microcontroller configured:

to apply voltage between the checking electrode and the working electrode, and between the counter electrode and the working electrode;

to detect the amounts of currents flowing through the working electrode;

to determine that the sample is properly injected if all of the amounts of the two currents are equal to or more than a predetermined threshold value;

to apply voltage between the working electrode and the counter electrode;

to re-detect the amount of current flowing through the working electrode; and

to acquire a concentration value as a sample reaction result corresponding to the amount of the re-detected current.