SYSTEMS AND METHODS FOR PRIMING SORBENT-BASED HEMODIALYSIS

• US 20120043279A1
• Filed: 08/31/2011
• Published: 02/23/2012
• Est. Priority Date: 11/05/2003
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Kelly, Thomas, Childers, Robert W., Busby, Don, Roger, Rodolfo, El Sayyid, Waleed Mutasem, Din, Shahid
• Granted Patent: US 9,072,830 B2
• Time in Patent Office: Days
• US Class Current: 210/638
• CPC Class Codes: A61M 1/1522 the interface being evacuated interfaces to enhance contact
• CPC Class Codes: A61M 1/153 the cassette being adapted for heating or cooling the treating fluid, e.g. the dialysate or the treating gas
• CPC Class Codes: A61M 1/154 with sensing means or components thereof
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/15625 the reservoirs acting as balance chambers
• CPC Class Codes: A61M 1/1563 Details of incorporated filters
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1601 Control or regulation
• CPC Class Codes: A61M 1/1607 before use, i.e. upstream of dialyser
• CPC Class Codes: A61M 1/1613 Profiling or modelling of patient or predicted treatment evolution or outcome
• CPC Class Codes: A61M 1/1621 Constructional aspects thereof semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 1/1629 with integral heat exchanger
• CPC Class Codes: A61M 1/1633 with more than one dialyser unit
• CPC Class Codes: A61M 1/1635 with volume chamber balancing devices between used and fresh dialysis fluid
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/166 Heating for sterilisation A61M1/1686
• CPC Class Codes: A61M 1/1668 Details of containers
• CPC Class Codes: A61M 1/167 Flexible packaging for solid concentrates
• CPC Class Codes: A61M 1/1672 : using membrane filters, e.g. for sterilising the dialysate
• CPC Class Codes: A61M 1/1696 : with dialysate regeneration
• CPC Class Codes: A61M 1/267 : used for pumping
• CPC Class Codes: A61M 1/288 : Priming priming in extracorporeal blood circuits A61M1/3643
• CPC Class Codes: A61M 1/3401 : Cassettes therefor
• CPC Class Codes: A61M 1/341 : by measuring the filtrate rate or volume
• CPC Class Codes: A61M 1/3417 : using distinct filters for dialysis and ultra-filtration
• CPC Class Codes: A61M 1/342 : Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3427 : back through the membrane, e.g. by inverted trans-membrane pressure [TMP]
• CPC Class Codes: A61M 1/3431 : upstream of the filter
• CPC Class Codes: A61M 1/3434 : with pre-dilution and post-dilution
• CPC Class Codes: A61M 1/3437 : downstream of the filter, e.g. post-dilution with filtrate
• CPC Class Codes: A61M 1/3444 : in which the collected ultra-filtrate expels an equal volume of substitution fluid from a reservoir
• CPC Class Codes: A61M 1/3451 : the difference in weight between both ultra-filtrate and substitution reservoir being used as control signal
• CPC Class Codes: A61M 1/3458 : having electrolytes not present in the dialysate
• CPC Class Codes: A61M 1/3465 : using dialysate as substitution fluid
• CPC Class Codes: A61M 1/3468 : using treated filtrate as substitution fluid
• CPC Class Codes: A61M 1/3472 : with treatment of the filtrate
• CPC Class Codes: A61M 1/3486 : Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
• CPC Class Codes: A61M 1/3621 : Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/362223 : the interface being evacuated interfaces to enhance contact
• CPC Class Codes: A61M 1/36224 : with sensing means or components thereof
• CPC Class Codes: A61M 1/36225 : with blood pumping means or components thereof
• CPC Class Codes: A61M 1/362261 : at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/362265 : Details of valves
• CPC Class Codes: A61M 1/3624 : Level detectors; Level control
• CPC Class Codes: A61M 1/3626 : Gas bubble detectors
• CPC Class Codes: A61M 1/3627 : Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
• CPC Class Codes: A61M 1/3643 : Priming, rinsing before or after use
• CPC Class Codes: A61M 1/3644 : Mode of operation
• CPC Class Codes: A61M 1/3646 : Expelling the residual body fluid after use, e.g. back to the body
• CPC Class Codes: A61M 1/3647 : with recirculation of the priming solution
• CPC Class Codes: A61M 1/3649 : using dialysate as priming or rinsing liquid
• CPC Class Codes: A61M 1/365 : through membranes, e.g. by inverted trans-membrane pressure [TMP]
• CPC Class Codes: A61M 1/3652 : using gas, e.g. air
• CPC Class Codes: A61M 1/3656 : Monitoring patency or flow at connection sites; Detecting disconnections
• CPC Class Codes: A61M 2202/0413 : Blood
• CPC Class Codes: A61M 2205/12 : with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/127 : with provisions for heating or cooling
• CPC Class Codes: A61M 2205/13 : with means for the detection of operative contact with patient, e.g. lip sensor
• CPC Class Codes: A61M 2205/15 : Detection of leaks
• CPC Class Codes: A61M 2205/18 : with alarm
• CPC Class Codes: A61M 2205/276 : preventing unwanted use
• CPC Class Codes: A61M 2205/3317 : Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3324 : PH measuring means
• CPC Class Codes: A61M 2205/3327 : Measuring
• CPC Class Codes: A61M 2205/3331 : Pressure; Flow
• CPC Class Codes: A61M 2205/3334 : Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3337 : Controlling, regulating pressure or flow by means of a valve by-passing a pump
• CPC Class Codes: A61M 2205/3344 : Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/3368 : Temperature
• CPC Class Codes: A61M 2205/3379 : Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/3393 : by weighing the reservoir
• CPC Class Codes: A61M 2205/3553 : remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3561 : local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3584 : using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/502 : User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/505 : Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2205/52 : with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/75 : with filters
• CPC Class Codes: A61M 60/113 : in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/258 : Piston pumps
• CPC Class Codes: A61M 60/279 : Peristaltic pumps, e.g. roller pumps
• CPC Class Codes: A61M 60/37 : Haemodialysis, haemofiltration or diafiltration
• CPC Class Codes: A61M 60/43 : using vacuum at the blood pump, e.g. to accelerate filling
• CPC Class Codes: A61M 60/508 : Electronic control means, e.g. for feedback regulation
• CPC Class Codes: A61M 60/847 : arranged in a cassette
• CPC Class Codes: A61M 60/849 : Disposable parts
• CPC Class Codes: A61M 60/851 : Valves

Abstract

A method for priming a hemodialysis treatment includes (i) providing a sorbent cartridge for cleaning spent dialysate fluid returning from a dialyzer: (ii) preparing a batch of dialysate in a quantity commensurate with being recycled through the sorbent cartridge multiple times; (iii) priming a dialysate circuit in fluid communication with the dialyzer using the batch of dialysate; and (iv) reversing a blood pump at least one time to prime a blood circuit in fluid communication with the dialyzer using a biologically safe fluid other than dialysate.

Claims

1. A method for priming a hemodialysis treatment comprising:

providing a sorbent cartridge for cleaning spent dialysate fluid returning from a dialyzer;

preparing a batch of dialysate in a quantity commensurate with being recycled through the sorbent cartridge multiple times;

priming a dialysate circuit in fluid communication with the dialyzer using the batch of dialysate; and

reversing a blood pump at least one time to prime a blood circuit in fluid communication with the dialyzer using a biologically safe fluid other than dialysate.

2. The method of claim 1, wherein the biologically safe fluid is saline and which includes pulling the saline from a saline source.

3. The method of claim 1, wherein preparing the batch includes mixing water and concentrate.

4. The method of claim 1, wherein preparing the batch includes using on the order of five liters of water to mix the dialysate.

5. The method of claim 1, wherein priming the blood circuit includes venting air through a vent.

6. The method of claim 1, wherein priming the blood circuit includes connecting the ends of arterial and venous lines of the blood circuit together.

7. The method of claim 1, which includes opening and closing at least one valve in the blood circuit in combination with the reversing of the blood pump at least one time to prime the blood circuit.

8. The method of claim 1, which includes, in combination with reversing the blood pump, opening and closing (i) a first valve operating with the blood circuit on a first side of an inlet of the biologically safe fluid to the blood circuit and (ii) a second valve operating with the blood circuit on a second side of the inlet.

9. The method of claim 1, which includes drawing the biologically safe fluid into the blood circuit and pushing the biologically safe fluid at one time in a first direction towards an air trap located in the blood circuit and at another time in a second direction towards a dialyzer located in the blood circuit.

10. The method of claim 1, which includes drawing the biologically safe fluid into the blood circuit and pushing the biologically safe fluid at one time in a therapy operation direction and at another time in a reverse of the therapy operation direction.

11. The method of claim 1, which includes beginning the priming of the dialysate circuit prior to beginning the priming of the blood circuit.

12. A method for priming a hemodialysis treatment comprising:

providing a sorbent cartridge for cleaning spent dialysate fluid returning from a dialyzer;

preparing a batch of dialysate in a quantity commensurate with being recycled through the sorbent cartridge multiple times;

priming a dialysate circuit in fluid communication with the dialyzer using the batch dialysate; and

priming a blood circuit by allowing a biologically safe fluid to be drawn into the blood circuit and to flow in different directions within the blood circuit.

13. The method of claim 12, which includes drawing the biologically safe fluid into the blood circuit via a blood pump.

14. The method of claim 12, which includes flowing the biologically safe fluid in different directions within the blood circuit using a blood pump.

15. The method of claim 14, which includes reversing the blood pump.

16. A dialysis machine configured and arranged to perform the method of claim 12.

17. A dialysis system comprising:

a batch container;

a sorbent cartridge;

first and second dialysate pumps;

a blood pump;

a source of biologically safe fluid;

a dialyzer;

a dialysate circuit (i) in fluid communication with the batch container, the sorbent cartridge, and the dialyzer and (ii) in operable communication with the first and second dialysate pumps;

a blood circuit (i) in fluid communication with the source of biologically safe fluid and the dialyzer and (ii) in operable communication with the blood pump; and

at least one processor configured and arranged to operate a priming sequence in which (i) dialysate prepared in the batch container is flowed through the dialysate circuit and (ii) biologically safe fluid is drawn from the source and flowed through the blood circuit.

18. The dialysis system of claim 17, wherein the at least one processor is configured and arranged to operate at least one of the dialysate first and second dialysate pumps to flow the dialysate through the dialysate circuit.

19. The dialysis system of claim 17, wherein the at least one processor is configured and arranged to operate the blood pump to draw the biologically safe fluid from the source.

20. The dialysis system of claim 17, wherein the at least one processor is configured and arranged to operate the blood pump to flow the biologically safe fluid through the blood circuit.

21. The dialysis system of claim 20, wherein the at least one processor is configured and arranged to reverse the blood pump to flow the biologically safe fluid through the blood circuit.