Anticancer Methods Employing Extracts of Gleditsia sinensis Lam
First Claim
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1. A method of treating a patient having estrogen receptor (ER) negative breast cancer, comprising administering to the patient a therapeutically effective amount of an agent selected from the group consisting of an extract of Gleditsia sinensis Lam, oleanolic acid, a pharmaceutically acceptable salt of oleanolic acid, and a combination of two or more thereof.
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Abstract
Selective apoptotic extracts of Gleditsia sinensis Lam are provided. Also provided are methods of using said extracts to induce apoptosis in specific cells, especially in a human. Provided as well are uses of the extracts of Gleditsia sinensis Lam for the preparation of a medicament for the selective induction of apoptosis.
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30 Claims
- 1. A method of treating a patient having estrogen receptor (ER) negative breast cancer, comprising administering to the patient a therapeutically effective amount of an agent selected from the group consisting of an extract of Gleditsia sinensis Lam, oleanolic acid, a pharmaceutically acceptable salt of oleanolic acid, and a combination of two or more thereof.
- 7. A pharmaceutical composition comprising a therapeutically effective amount of an agent selected from the group consisting of an extract of Gleditsia sinensis Lam, oleanolic acid, a pharmaceutically acceptable salt of oleanolic acid, and combinations of two or more thereof, wherein the therapeutically effective amount is an amount effective to treat estrogen receptor (ER) negative breast cancer.
- 13. A method of treating a patient having cancer that does not express an estrogen receptor (ER), comprising administering a therapeutically effective amount of an agent selected from the group consisting of an extract of Gleditsia sinensis Lam, oleanolic acid, a pharmaceutically acceptable salt of oleanolic acid, and combinations of two or more thereof.
- 17. A pharmaceutical composition comprising a therapeutically effective amount of an agent selected from the group consisting of an extract of Gleditsia sinensis Lam, oleanolic acid, or a pharmaceutically acceptable salt of oleanolic acid, wherein the therapeutically effective amount of the agent is an about that is effective to treat a cancer that does not express an estrogen receptor (ER).
- 21. A method of treating a patient having estrogen receptor (ER) negative breast cancer, comprising administering a therapeutically effective amount of at least one saponin, or a pharmaceutically acceptable salt thereof, to the patient, wherein the saponin possesses mTORC1, mTORC2, and/or possesses Akt inhibitory activity, and/or disrupts lipid rafts (LRs) in vitro.
- 24. A pharmaceutical composition comprising a therapeutically effective amount of at least one saponin, or a pharmaceutically acceptable salt thereof, wherein the saponin possesses mTORC1, mTORC2, and/or possesses Akt inhibitory activity, and/or disrupts lipid rafts (LRs) in vitro.
- 27. A method of treating a patient having cancer that does not express an estrogen receptor (ER), comprising administering a therapeutically effective amount of a saponin to the patient, wherein the saponin possesses mTORC1, mTORC2, and/or possesses Akt inhibitory activity, and/or disrupts lipid rafts (LRs) in vitro.
Specification