ANALYTE SENSING BIOINTERFACE

• US 20120046534A1
• Filed: 10/31/2011
• Published: 02/23/2012
• Est. Priority Date: 04/15/2005
• Status: Abandoned Application

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Simpson, Peter C., Brauker, James H.
• Application Number:
  US13/285,880
• Publication Number:
  US 20120046534A1
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.

Claims

1. A glucose sensor configured for implantation in a host, comprising:

a biocompatible matrix comprising a scaffolding having a porosity;

a working electrode comprising an electrically conductive material, wherein an electroactive surface of the working electrode is distributed throughout the biocompatible matrix; and

electronics electrically coupled to the working electrode, wherein, in use, the electronics are configured to detect a current flowing through the working electrode or a voltage of the working electrode, wherein the current or voltage is indicative of a quantity of an analyte within the porosity.

2. The glucose sensor of claim 1, wherein the scaffolding comprises an electrically non-conductive material.

3. The glucose sensor of claim 2, wherein the scaffolding further comprises an electrically conductive material.

4. The glucose sensor of claim 1, wherein the scaffolding is substantially planar.

5. The glucose sensor of claim 1, wherein the biocompatible matrix comprises an enzyme.

6. The glucose sensor of claim 5, wherein the biocompatible matrix further comprises a resistance domain disposed over the enzyme.

7. The glucose sensor of claim 5, wherein the biocompatible matrix further comprises a bioactive agent.

8. A sensor for measuring glucose in a host, the sensor comprising:

a biointerface, the biointerface comprising a porous biointerface material, wherein electroactive surfaces are distributed within at least some pores in the biointerface, and wherein the electroactive surfaces have a membrane coating disposed thereon; and

electronics electrically coupled to the sensor, such that, in use, the electronics are configured to detect a current or a voltage indicative of a quantity of glucose within the pores.

9. The sensor of claim 8, wherein the biointerface comprises an electrically non-conductive material.

10. The sensor of claim 9, wherein the biointerface further comprises an electrically conductive material.

11. The sensor of claim 8, wherein the biointerface is substantially planar.

12. The sensor of claim 8, wherein the biointerface comprises an enzyme.

13. The sensor of claim 12, wherein the biointerface further comprises a resistance domain disposed over the enzyme.

14. The sensor of claim 8, wherein the biointerface further comprises a bioactive agent.