ANALYTE SENSING BIOINTERFACE
First Claim
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1. A glucose sensor configured for implantation in a host, comprising:
- a biocompatible matrix comprising a scaffolding having a porosity;
a working electrode comprising an electrically conductive material, wherein an electroactive surface of the working electrode is distributed throughout the biocompatible matrix; and
electronics electrically coupled to the working electrode, wherein, in use, the electronics are configured to detect a current flowing through the working electrode or a voltage of the working electrode, wherein the current or voltage is indicative of a quantity of an analyte within the porosity.
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Abstract
Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.
181 Citations
14 Claims
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1. A glucose sensor configured for implantation in a host, comprising:
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a biocompatible matrix comprising a scaffolding having a porosity; a working electrode comprising an electrically conductive material, wherein an electroactive surface of the working electrode is distributed throughout the biocompatible matrix; and electronics electrically coupled to the working electrode, wherein, in use, the electronics are configured to detect a current flowing through the working electrode or a voltage of the working electrode, wherein the current or voltage is indicative of a quantity of an analyte within the porosity. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A sensor for measuring glucose in a host, the sensor comprising:
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a biointerface, the biointerface comprising a porous biointerface material, wherein electroactive surfaces are distributed within at least some pores in the biointerface, and wherein the electroactive surfaces have a membrane coating disposed thereon; and electronics electrically coupled to the sensor, such that, in use, the electronics are configured to detect a current or a voltage indicative of a quantity of glucose within the pores. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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Specification