MEDICAL DEVICE FOR GLUCOSE MONITORING OR REGULATION
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Accused Products
Abstract
A medical device comprising a pressure generating means adapted to displace a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration.
23 Citations
56 Claims
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1-28. -28. (canceled)
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29. A medical device comprising:
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an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the medium surrounding the implantable member; a bidirectional pressure generating means configured to suck and expel liquid through the analyte responsive porous membrane; and a sensor adapted to measure a flow resistance of said liquid through the analyte responsive porous membrane. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A method of operating a medical device comprising an implantable member with an analyte responsive porous membrane which changes its porosity subject to changes in an analyte concentration occurring in a fluid surrounding the analyte responsive porous membrane, comprising:
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sucking in a discrete volume of said fluid surrounding the analyte responsive porous membrane into the implantable member; pumping a liquid from a reservoir in one or more discrete pre-determined volumes towards the analyte responsive porous membrane thereby expelling the said sucked in volume of fluid; measuring a flow resistance of the fluid through the analyte responsive porous membrane; and determining an analyte concentration based on the measured flow resistance. - View Dependent Claims (41, 42, 43)
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44. A method of measuring an analyte concentration, the method comprising the steps of:
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providing a medical device comprising a reservoir containing a liquid, and an implantable member having an analyte responsive porous membrane which changes its porosity subject to changes in analyte concentration occurring in a fluid surrounding the analyte responsive porous membrane; sucking in a discrete volume of said fluid surrounding the analyte responsive porous membrane into the implantable member; pumping said liquid from said reservoir in one or more discrete pre-determined volumes towards the analyte responsive porous membrane thereby expelling the said sucked in discrete volume of fluid; and determining an analyte concentration based on the measured flow resistance of fluid displaced through the analyte responsive membrane. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51)
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52. A method of administering a drug for influencing an analyte level in a patient, the method comprising:
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measuring an analyte concentration said measuring of the analyte concentrate comprising; providing a medical device comprising a reservoir containing a liquid, and an implantable member having an analyte responsive porous membrane which changes its porosity subject to changes in analyte concentration occurring in a fluid surrounding the analyte responsive porous membrane; sucking in a discrete volume of said fluid surrounding the analyte responsive porous membrane into the implantable member; pumping said liquid from said reservoir in one or more discrete pre-determined volumes towards the analyte responsive porous membrane thereby expelling the said sucked in discrete volume of fluid; and determining a analyte concentration based on the measured flow resistance of fluid displaced through the analyte responsive membrane; and delivering a drug capable of influencing an analyte level in a patient according to the measured analyte concentration. - View Dependent Claims (53, 54)
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55. A method of measuring the concentration of an analyte in interstitial fluid including the steps of:
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providing a medical device comprising a pressure generating means, a member implantable through the skin of a patient having a lumen which is fluidically connected to the pressure generating means and an analyte responsive porous membrane between lumen and surrounding medium, a means connected with the lumen of the implantable member to measure a signal related to the flow resistance in the fluid path, and calculation means; extraction of body interstitial fluid through the porous membrane by applying under-pressure sufficient to fill the lumen of the implantable member; discharging a portion of liquid towards the analyte responsive membrane, thereby measuring the relaxation of the applied pressure, which is in relation to the analyte concentration of the surrounding medium; discharging one or more additional portions of liquid from the reservoir through the membrane, thereby measuring the relaxation of the applied pressure, which is in relation to the known analyte concentration in the reservoir; and calculating the analyte concentration based on the relaxation of the pressure after pumping, using the measurement at the known concentration from reservoir as reference. - View Dependent Claims (56)
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Specification