INTRALUMINAL SCAFFOLD HAVING AN ENLARGED PORTION

• US 20120046729A1
• Filed: 04/14/2011
• Published: 02/23/2012
• Est. Priority Date: 04/14/2010
• Status: Abandoned Application

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Vascular
• Inventors: von Oepen, Randolf, Ehrenreich, Kevin J., Yribarren, Travis R.
• Application Number:
  US13/087,341
• Publication Number:
  US 20120046729A1
• Time in Patent Office: Days
• US Class Current: 623/1.15
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2002/825 having longitudinal struts
• CPC Class Codes: A61F 2002/8483 Barbs
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2002/91566 connected trough to trough
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61F 2230/0078 hyperboloidal

Abstract

Devices and methods for treating veins and venous conditions, such as chronic cerebrospinal venous insufficiency, are provided. In one aspect, the disclosed subject matter provides an intraluminal scaffold having a generally tubular body with a lumen defined therethrough, the tubular body having a compressed condition for delivery and an expanded condition for implant within a vessel having a distended portion, at least a length of the tubular body configured to form an enlarged portion in the expanded condition to engage a wall of the distended portion of the vessel. Methods for fabricating and using the scaffold, methods for remodeling a vein, and methods of deploying a medical device in a vessel without negatively impacting the function of a valve of the vessel, are also provided.

Claims

1. An intraluminal scaffold having a generally tubular body with a lumen defined therethrough, the tubular body having a compressed condition for delivery and an expanded condition for implant within a vessel having a distended portion, at least a length of the tubular body configured to form an enlarged portion in the expanded condition to engage a wall of the distended portion of the vessel.

2. The intraluminal scaffold of claim 1, wherein the enlarged portion has a barrel shape.

3. The intraluminal scaffold of claim 2, wherein the enlarged portion of the tubular body includes a pattern of cells substantially uniform in size when the scaffold is in the expanded condition.

4. The intraluminal scaffold of claim 2, wherein the enlarged portion is formed of a continuous curved strut.

5. The intraluminal scaffold of claim 1, wherein the enlarged portion has a shape selected from a buttercup shape, a bulbous shape, an hourglass shape, a dumbbell shape, a tapered shape, a flared shape, and a corrugated shape.

6. The intraluminal scaffold of claim 1, wherein the enlarged portion includes a spiral-shaped wire.

7. The intraluminal scaffold of claim 1, wherein the enlarged portion of the tubular body in the expanded condition conforms to the wall of the distended portion of the vessel.

8. The intraluminal scaffold of claim 1, wherein the scaffold is a conforming scaffold.

9. The intraluminal scaffold of claim 1, wherein the scaffold is a supporting scaffold.

10. The intraluminal scaffold of claim 1, wherein at least a portion of the scaffold is balloon expandable.

11. The intraluminal scaffold of claim 1, wherein at least a portion of the scaffold is self-expandable.

12. The intraluminal scaffold of claim 1, wherein the tubular body further comprises a cylindrical portion in the expanded condition extending from at least one end of the enlarged portion of the tubular body.

13. The intraluminal scaffold of claim 12, wherein the enlarged portion in the expanded condition has a profile larger than a diameter of the cylindrical portion in the expanded condition.

14. The intraluminal scaffold of claim 12, wherein the enlarged portion is disposed at an end of the scaffold.

15. The intraluminal scaffold of claim 12, further including a second cylindrical portion extending from a second end of the enlarged portion.

16. The intraluminal scaffold of claim 12, wherein the enlarged portion includes a bistable construction.

17. The intraluminal scaffold of claim 16, wherein the enlarged portion in the expanded condition has a profile larger than a diameter of the cylindrical portion in the expanded condition.

18. The intraluminal scaffold of claim 16, wherein the enlarged portion has sufficient flexibility to conform to the distended portion of the vessel without plastic deformation.

19. The intraluminal scaffold of claim 12, wherein the cylindrical portion is formed of a material different than the enlarged portion.

20. The intraluminal scaffold of claim 19, wherein the cylindrical portion is formed from a material that plastically deforms when expanded to the expanded condition.

21. The intraluminal scaffold of claim 1, wherein the scaffold is made of a degradable material.

22. The intraluminal scaffold of claim 21, wherein the degradable material is capable of extravascular degradation.

23. The intraluminal scaffold of claim 1, wherein the tubular body includes a side opening defined therein.

24. The intraluminal scaffold of claim 23, wherein the tubular body further comprises a side branch in communication with the side opening to accommodate a vessel bifurcation.

25. The intraluminal scaffold of claim 1, further comprising a restraining band to induce formation of the enlarged portion when expanded to the expanded condition.

26. The intraluminal scaffold of claim 1, wherein the tubular body conforms to the wall of the vessel during vessel relaxation due to adjustments in fluid flow.

27. The intraluminal scaffold of claim 1, wherein the tubular body recoils from its initial expanded condition over a period of time greater than one day.

28. The intraluminal scaffold of claim 27, wherein the tubular member is formed of a degradable material.

29. The intraluminal scaffold of claim 27, wherein the tubular member recoils from its initial expanded condition due to degradation of the degradable material.

30. The intraluminal scaffold of claim 1, wherein at least a portion of the tubular member is formed of a material selected from a polymeric material, a metallic material, a shape-memory material, and a degradable material.

31. The intraluminal scaffold of claim 1, further comprising a therapeutic substance.

32. The intraluminal scaffold of claim 31, wherein the therapeutic substance includes one or more of fondaparinux, Enoxaparin, Bivaliruden, a factor Xa inhibitor, a collagenase, and endopeptidase.

33. The intraluminal scaffold of claim 1, further comprising an integrated filter system.

34. The intraluminal scaffold of claim 1, wherein the enlarged portion of the tubular body has a non-cylindrical shape.